Highly selective and sensitive glucose sensors based on organic electrochemical transistors with graphene-modified gate electrodes
Highly selective and sensitive glucose sensors based on organic electrochemical transistors with graphene-modified gate electrodes
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DOI：
10.1039/c3tb20451k
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发表时间：
2013-01-01
影响因子：
7
通讯作者：
Yan, Feng
中科院分区：
文献类型：
--
作者：
Liao, Caizhi;Zhang, Meng;Yan, Feng
首次将石墨烯或还原氧化石墨烯（rGO）与酶（葡萄糖氧化酶）共修饰在栅电极上，提高了基于有机电化学晶体管（OECT）的葡萄糖传感器的灵敏度。优化后的器件在10 nM至1 μ M的宽浓度范围内显示出对葡萄糖的线性响应，检测限低至10 nM，比没有石墨烯修饰的器件好两个数量级。首次系统地研究了器件的选择性。当用生物相容性聚合物（壳聚糖或Nafion）修饰栅电极时，器件选择性显著提高。尿酸和L-抗坏血酸的干扰作用在实际应用中几乎可以忽略不计。因此，可以通过使栅电极功能化来实现高灵敏度和选择性的基于OECT的葡萄糖传感器。此外，该装置是溶液可处理的并且成本低，因此适合于一次性感测应用。
The sensitivity of glucose sensors based on organic electrochemical transistors (OECT) is increased by co-modifying graphene or reduced graphene oxide (rGO) and enzyme (glucose oxidase) on the gate electrodes for the first time. The optimized device shows linear responses to glucose in a broad concentration region from 10 nM to 1 mu M and with a detection limit down to 10 nM, which is two orders of magnitude better than that for the device without the graphene modification. The selectivity of the device is systematically studied for the first time. The device selectivity is dramatically improved when the gate electrode is modified with biocompatible polymers (chitosan or Nafion). The interfering effect caused by uric acid and L-ascorbic acid is almost negligible for practical applications. Therefore, highly sensitive and selective OECT-based glucose sensors can be realized by functionalizing the gate electrodes. In addition, the devices are solution processable and low-cost, and are thus suitable for disposable sensing applications.