Lithium in the treatment of mood disorders.
Lithium in the treatment of mood disorders.
复制标题
DOI：
10.1056/nejm199409013310907
复制
发表时间：
1994-09
期刊：
影响因子：
--
通讯作者：
L. Price;G. Heninger
中科院分区：
文献类型：
--
作者：
L. Price;G. Heninger
虽然锂对躁狂症的作用首次被描述已经过去了40多年，但锂仍然是治疗情绪障碍的主要药物。事实上，它仍然是衡量新的情绪稳定或情绪激动药物的标准。考虑到锂的治疗指数较窄，而且其作用机制尚不清楚，这种长寿就更加引人注目了。本文综述了锂的历史、药理学、疗效、临床应用和毒性，并简要讨论了锂的替代品或替代品。历史锂，其原子序数为3，是。. .
Although over 40 years have elapsed since its effects on mania were first described,1 lithium is still a mainstay in the treatment of mood disorders. Indeed, it remains the standard against which new mood-stabilizing, or thymoleptic, drugs are measured. This longevity is all the more remarkable given lithium's narrow therapeutic index and the lack of clarity about its mechanism of action. This review summarizes the history, pharmacology, efficacy, clinical use, and toxicity of lithium, with a brief discussion of other thymoleptic drugs proposed as alternatives or adjuncts to lithium. History Lithium, which has an atomic number of 3, is the . . .