Dietary fat and apolipoprotein genotypes modulate plasma lipoprotein levels in Brazilian elderly women
Dietary fat and apolipoprotein genotypes modulate plasma lipoprotein levels in Brazilian elderly women
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DOI：
10.1007/s11010-009-0313-0
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发表时间：
2010-04-01
影响因子：
4.3
通讯作者：
Nobrega, O. T.
中科院分区：
文献类型：
--
作者：
Paula, R. S.;Souza, V. C.;Nobrega, O. T.
研究表明，负责脂质运输的载脂蛋白基因多态性易患动脉粥样硬化性血脂异常。本研究旨在调查载脂蛋白E、A5和B基因型和饮食摄入量对巴西老年妇女血脂谱的影响。居住在巴西联邦区郊区的252名妇女(60岁或以上)接受了临床和实验室评估，以确定血糖和血脂变量的特征，并排除混杂因素(吸烟、饮酒、激素替代、认知障碍、体力活动)。三天的食物记录被用来确定通常的饮食摄入量，而基因分型评估是按照既定的方法进行的。基因频率符合Hardy-Weinberg平衡。在调整前，携带epsilon 2等位基因的个体与epsilon 4携带者相比，血清甘油三酯(P<；0.05)和极低密度脂蛋白(P<；0.005)水平更高，而epsilon 4携带者的低密度脂蛋白水平显著高于epsilon 2携带者。在总脂肪摄入量高或多不饱和与饱和脂肪酸比率低的情况下，epsilon 4携带者失去了对高甘油三酯血症的保护作用。与脂肪摄入方案无关，载脂蛋白A5和B基因型与血脂水平无关。结果提示绝经后妇女中存在一种类似于β-脂蛋白血症的表型，具有显著的基因-饮食交互作用。
Studies show that genetic polymorphisms in apolipoproteins, which are in charge of lipid transport, predispose to atherogenic dyslipidemia. This study aimed to investigate the impact of apolipoprotein E, A5, and B genotypes and dietary intake on lipid profile in a sample of elderly women in Brazil. Two hundred and fifty-two women (60 years or older) living in the outskirts of the Brazilian Federal District underwent clinical and laboratory assessments to characterize glycemic and lipidemic variables, and also to exclude confounding factors (smoking, drinking, hormone replacement, cognitive impairment, physical activity). Three-day food records were used to determine usual dietary intake, whereas genotypic evaluations were in accordance to established methodologies. Genotype frequencies were consistent with the Hardy-Weinberg equilibrium. Prior to adjustment, individuals carrying the epsilon 2 allele showed higher serum levels of triglycerides (P < 0.05) and VLDL (P < 0.005) compared to epsilon 4 carriers, whereas LDL levels were considerably elevated in epsilon 4 compared to epsilon 2 carriers. In the presence of high intake of total fat or a low ratio of polyunsaturated to saturated fatty acid, epsilon 4 carriers lost protection against hypertriglyceridemia. There was no association of the apolipoprotein A5 and B genotypes with lipidemic levels independently of the fat intake regimen. Results are suggestive of a dysbetalipoproteinemic-like phenotype in postmenopausal women, with remarkable gene-diet interaction.