Patterns of major depression and drug-related problems amongst heroin users across 36 months
Patterns of major depression and drug-related problems amongst heroin users across 36 months
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DOI：
10.1016/j.psychres.2007.12.007
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发表时间：
2009-03-31
影响因子：
11.3
通讯作者：
Havard, Alys
中科院分区：
文献类型：
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作者：
Darke, Shane;Mills, Katherine;Havard, Alys
该研究旨在确定36个月内重度抑郁症（MD）的模式，以及与海洛因依赖治疗结果的关系。作为纵向队列研究的一部分，429名海洛因使用者在36个月的随访中接受了采访。MD从基线时的23.8%下降到36个月时的8.2%。女性在基线时（31.1 vs. 19.8）和36个月时（11.9 vs. 6.1%）更容易患MD。基线时患有MD的患者在随访时（40.2 vs. 15.9%）和36个月时（14.7 vs. 6.1%）被诊断为MD的可能性显著增加。在36个月的时间里，抗抑郁药的使用在男女之间都没有减少。基线MD与36个月的治疗暴露无关。36个月时，药物使用和与毒品有关的问题大幅下降，身体健康得到改善，各组之间没有明显差异。尽管总体心理健康有所改善，但在基线和36个月时，基线时患有MD的患者的SF12心理健康评分均显著降低。结果表明，除抑郁外，抑郁海洛因使用者的预后并不比非抑郁海洛因使用者差。2007爱思唯尔爱尔兰有限公司版权所有。
The study aimed to determine patterns of major depression (MD) across 36 months, and the relationship to outcomes for the treatment of heroin dependence. As part of a longitudinal cohort study, 429 heroin users were interviewed at 36 month follow-up. MD declined from 23.8% at baseline to 8.2% at 36 months. Females were more likely to have MD at both baseline (31.1 vs. 19.8) and 36 months (11.9 vs. 6.1%). Those with MD at baseline were significantly more likely to be diagnosed with MD at a follow-up interview (40.2 vs. 15.9%) and at 36 months (14.7 vs. 6.1%). Antidepressant use did not decrease across 36 months amongst either gender. Baseline MD was not related to treatment exposure across 36 months. There were large and significant declines in drug use and drug-related problems, and improvements in physical health with no group differences evident at 36 months. Despite improvements in global mental health, at both baseline and 36 months those with MD at baseline had significantly lower SF12 mental health scores. It was concluded that, with the exception of depression, the prognosis of depressed heroin users is not worse than that of non-depressed users. (c) 2007 Elsevier Ireland Ltd. All rights reserved.