Pediatric gliomas as neurodevelopmental disorders.
Pediatric gliomas as neurodevelopmental disorders.
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作者：
Baker SJ;Ellison DW;Gutmann DH
脑肿瘤是儿童期最常见的实体瘤，其中神经胶质瘤占这些癌症的最大比例。有几个特征将他们与成年人区分开来，包括他们的自然历史，致病基因突变和大脑位置。这些独特的性质表明，其发展和维护的细胞和分子病因可能是不同的成人胶质瘤的发生和生长。在这篇综述中，我们在发育神经生物学的背景下讨论了儿童低级别和高级别胶质瘤的遗传基础，并强调了儿童和成人中出现的组织学相似肿瘤之间的差异。
Brain tumors represent the most common solid tumor of childhood, with gliomas comprising the largest fraction of these cancers. Several features distinguish them from their adult counterparts, including their natural history, causative genetic mutations, and brain locations. These unique properties suggest that the cellular and molecular etiologies that underlie their development and maintenance might be different from those that govern adult gliomagenesis and growth. In this review, we discuss the genetic basis for pediatric low-grade and high-grade glioma in the context of developmental neurobiology, and highlight the differences between histologically-similar tumors arising in children and adults.