Formal Synthesis of (–)-Siccanin Using an Enantioselective Domino Wacker/Carbonylation/Methoxylation Reaction
Formal Synthesis of (–)-Siccanin Using an Enantioselective Domino Wacker/Carbonylation/Methoxylation Reaction
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使用对映选择性 Domino Wacker/羰基化/甲氧基化反应正式合成 (â)-Siccanin
DOI：
10.1055/s-0035-1560752
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发表时间：
2016
期刊：
影响因子：
2
通讯作者：
J.R. Reiner
中科院分区：
文献类型：
--
作者：
L.F. Tietze;S. Jackenkroll;D. Ganapathy;J.R. Reiner
通过对映选择性多米诺瓦克/羰基化/甲氧基化反应正式合成(-)-siccanin，这是形成具有95% ee的四元立体中心的chroman环的关键步骤。悬垂的环己基部分是通过两步醛缩反应引入的。
A formal synthesis of (–)-siccanin was achieved through an enantioselective domino Wacker/carbonylation/methoxylation reaction as the key step to form the chroman ring with a quaternary stereogenic center with 95% ee. The pendant cyclohexyl moiety was introduced through a two-step aldol condensation.