CATALYTIC ENANTIOSELECTIVE CONJUGATE ADDITION OF DIALKYLZINC COMPOUNDS TO CHALCONES
CATALYTIC ENANTIOSELECTIVE CONJUGATE ADDITION OF DIALKYLZINC COMPOUNDS TO CHALCONES
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DOI：
10.1002/cber.19921250530
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发表时间：
1992-05-01
期刊：
影响因子：
--
通讯作者：
FELDER, M
中科院分区：
文献类型：
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作者：
BOLM, C;EWALD, M;FELDER, M
由Ni(Acac)2与C2对称的2，2‘-联吡啶3或手性吡啶5-12形成的络合物催化二乙基锌与烯酮的共轭加成反应。产品的光学纯度可达89%ee。观察到配体的对映体过量与产物的ee之间有很强的正非线性关系。考察了影响催化剂活性和对映体选择性的因素。
Conjugate addition of diethylzinc to enones is catalyzed by a complex derived from Ni(acac)2 and C2-symmetric 2,2'-bipyridine 3 or chiral pyridines 5-12. The products are obtained with optical purities up to 89% ee. A strong positive nonlinear relationship between the enantiomeric excess of the ligand and the ee of the product has been observed. The factors which govern catalyst activity and enantioselectivity have been investigated.