Preparation and properties of novel hydrogels from oxidized konjac glucomannan cross-linked chitosan for in vitro drug delivery
Preparation and properties of novel hydrogels from oxidized konjac glucomannan cross-linked chitosan for in vitro drug delivery
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DOI：
10.1002/mabi.200700035
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发表时间：
2007-09-11
影响因子：
4.6
通讯作者：
Xiao, Chaobo
中科院分区：
文献类型：
--
作者：
Yu, Huiqun;Lu, Jun;Xiao, Chaobo
本文利用二醛魔芋葡甘聚糖（DAK）作为壳聚糖（CS）的大分子交联剂制备了一种新型复合水凝胶。这种生物相容性材料在几分钟内即可交联并凝胶化。通过各种分析来表征结构和形态。结果表明，水凝胶是通过CS链的氨基和DAK的醛基之间的希夫碱反应形成的。随着水凝胶中 DAK 含量的增加，交联密度 (rho(x)) 增加，而平衡溶胀比 (SR) 和交联间平均分子量 ((M) over bar (c)) 值减小。通过改变释放介质的 pH 值来评估药物释放，释放速率对水凝胶平衡 SR 的反向依赖性表明药物释放可能会因药物与聚合物的结合而受到阻碍。重要的是，与传统的小分子交联剂制备CS基水凝胶相比，该过程提供了一个全新的材料制备窗口。
In this paper, a novel composite hydrogel was prepared by the use of dialdehyde konjac glucomannan (DAK) as macromolecular cross-linking agent for chitosan (CS). This biocompatible material cross-links and gels in minutes. The structure and morphology were characterized by various analyses. The results indicate that the hydrogels formed through the Schiff-base reaction between the amino groups of CS chains and the aldehyde groups of DAK. The cross-link density (rho(x)) increases with the enhancement of DAK content in hydrogels, while equilibrium swelling ratio (SR) and the average molecular weight between cross-links ((M) over bar (c)) value decrease. Drug release was evaluated by varying pH of the release medium, reversed dependence of release rate on the equilibrium SR of hydrogel indicated that drug release may be impeded by the association of drug with the polymer. Importantly, this process offers an entirely new window of materials preparation when compared with the traditional preparation of CS-based hydrogel with small molecules cross-linking agent.