Human xenograft osteosarcoma models with spontaneous metastasis in mice: clinical relevance and applicability for drug testing
Human xenograft osteosarcoma models with spontaneous metastasis in mice: clinical relevance and applicability for drug testing
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DOI：
10.1007/s00432-006-0157-x
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发表时间：
2007-03-01
影响因子：
3.6
通讯作者：
Choong, Peter F. M.
中科院分区：
文献类型：
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作者：
Dass, Crispin R.;Ek, Eugene T. H.;Choong, Peter F. M.
过去 35 年来，人们一直在分离并培养源自患者的骨肉瘤细胞。但迄今为止，骨肉瘤模型的开发尚未取得重大突破，该模型使用人类骨肉瘤细胞的原位植入，并密切模拟这种使人衰弱和致命的疾病的临床进展。考虑到这种疾病具有毁灭性的人口统计学特征（儿科年龄组中癌症相关死亡的第二大原因），并且缺乏可靠的选择来控制该疾病（即使不能治愈），因为它也是最常见的原发性骨肿瘤，这种模型早就应该出现了。只有这样，才能进行更强有力的研发，寻找有效的抗骨肉瘤药物。这篇综述解决了这个难题，并列出了可用的各种模型（使用人类骨肉瘤细胞）以及使用这些模型进行的研究类型。
Osteosarcoma cells derived from patients have been isolated and subsequently cultured for the past 35 years. To date though, there have been no major break-throughs in the development of a model for osteosarcoma that uses orthotopic implantation of human osteosarcoma cells and that closely emulates the clinical progression of this debilitating and fatal disease. Such a model is long overdue given the devastating demographics (second highest cause of cancer-related death in the paediatric age group) of the ailment and the lack of solid options for control, if not cure, for the disease, as it also is the most common primary tumour of bone. Only then can more robust R & D be undertaken in the search for efficacious anti-osteosarcoma agents. This review tackles this conundrum and lists the variety of models (that use human osteosarcoma cells) available and the types of studies performed with these.