Regulation of human gonadotropins. 3. Luteinizing hormone and follicle stimulating hormone in sera from adult males.
Regulation of human gonadotropins. 3. Luteinizing hormone and follicle stimulating hormone in sera from adult males.
复制标题
人类促性腺激素的调节。
DOI：
10.1210/jcem-28-10-1473
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发表时间：
1968
期刊：
影响因子：
--
通讯作者：
R. Jaffe
中科院分区：
文献类型：
--
作者：
N. Peterson;A. Midgley;R. Jaffe
用放射免疫法测定健康男性血清中促卵泡激素（FSH）和促黄体生成素（LH）的浓度。在每天、每天3次或每小时采集的样本中，没有发现血清浓度的昼夜或其他节律变化的证据。3名受试者每天使用1.5 mg乙炔雌二醇治疗2-3天，结果血清FSH和LH浓度持续下降。3名受试者每天使用25mg丙酸睾酮治疗3天，结果血清LH浓度持续下降。4名受试者每天服用200毫克枸橼酸克罗米芬3天，结果血清FSH和LH浓度均升高。
ABSTRACT Radioimmunoassays for follicle stimulating hormone (FSH) and luteinizing hormone (LH) were used to determine the concentrations of these gonadotropins in sera from healthy men. No evidence of diurnal or other rhythmic variations in serum concentrations was found in samples obtained daily, 3 times a day, or hourly. Treatment of 3 subjects with 1.5 mg of ethinyl estradiol/day for 2–3 days resulted in a consistent fall in serum concentrations of both FSH and LH. Treatment of 3 subjects with 25 mg of testosterone propionate each day for 3 days resulted in a consistent fall in serum concentrations of LH. Treatment of 4 subjects with 200 mg of clomiphene citrate daily for 3 days resulted in a rise in serum concentrations of both FSH and LH.