Neuronal extracellular proteases facilitate cell migration, axonal growth, and pathfinding.
Neuronal extracellular proteases facilitate cell migration, axonal growth, and pathfinding.
复制标题
神经元细胞外蛋白酶促进细胞迁移、轴突生长和寻路。
DOI：
10.1007/s004410050942
复制
发表时间：
1997
影响因子：
3.6
通讯作者：
Haffke,SP
中科院分区：
文献类型：
--
作者：
Seeds,NW;Siconolfi,LB;Haffke,SP
轴突生长锥释放细胞外蛋白酶，通过消化前进生长锥路径上的细胞-细胞和细胞-基质接触来促进其运动。丝氨酸蛋白酶纤溶酶原激活剂（PA）在培养的哺乳动物神经元轴突生长锥中有分泌和局部集中。因此，pa在生长锥运动和轴突寻径过程中发挥积极作用。我们讨论了最近的发现，表明这些蛋白酶的生物作用比原来认为的更复杂。
The release of extracellular proteases by the axonal growth cone has been proposed to facilitate its movement by digesting cell-cell and cell-matrix contacts in the path of the advancing growth cone. The serine protease plasminogen activator (PA) has been shown to be secreted and focally concentrated at axonal growth cones of cultured mammalian neurons. Thus, PAs are well-placed to play an active role in growth cone movement and axonal pathfinding in development and regeneration. We discuss recent findings that suggest that the biological action of these proteases is more complex than originally thought.