Regulation of insulin-like growth factor-I and insulin-like growth factor binding protein-1 concentrations in preterm fetuses.
Regulation of insulin-like growth factor-I and insulin-like growth factor binding protein-1 concentrations in preterm fetuses.
复制标题
早产儿中胰岛素样生长因子-I 和胰岛素样生长因子结合蛋白-1 浓度的调节。
DOI：
10.1067/mob.2003.26
复制
发表时间：
2003
影响因子：
9.8
通讯作者：
L. Giudice
中科院分区：
文献类型：
--
作者：
J. Verhaeghe;E. Herck;J. Billen;P. Moerman;F. Assche;L. Giudice
目的
我们的目的是评估哪些因素调节胰岛素样生长因子-I和胰岛素样生长因子结合蛋白-1浓度在早产胎儿。
研究设计
我们研究了76例妊娠25至36周的单胎分娩。49例妊娠合并高血压疾病; 24例妊娠合并早产或胎膜早破; 49例妊娠产前给予糖皮质激素。病理报告显示69个胎盘中有31个存在梗死或血肿。记录脐动、静脉血气值，测定脐静脉血糖、C肽、胰岛素样生长因子-I和胰岛素样生长因子结合蛋白-1浓度。
结果
出生体重与脐静脉胰岛素样生长因子-I相关（r = 0.68，P <0.0001），与胰岛素样生长因子结合蛋白-1呈负相关（r =-0.26，P = 0.02）。出生体重</=第25百分位数的婴儿与>第25百分位数的婴儿相比，胰岛素样生长因子-I水平较低，但胰岛素样生长因子结合蛋白-1水平较高。双因素方差分析显示，脐静脉胰岛素样生长因子-I由胎龄（P =.0004）和出生体重百分位数（P <.0001）决定，而胰岛素样生长因子结合蛋白-1不受胎龄的影响。脐静脉C肽与胰岛素样生长因子结合蛋白-1高度相关（r =-0.55，P <0.0001），但与胰岛素样生长因子-I水平无关。脐动、静脉血气值，尤其是脐动脉PO（2）与脐静脉胰岛素样生长因子-I和胰岛素样生长因子结合蛋白-1相关（r分别为0.51和-0.48，P <0.0001）;胰岛素样生长因子-I和胰岛素样生长因子结合蛋白-1的变化发生在脐动脉PO（2）<14.8 mm Hg时。多元回归分析显示，脐静脉胰岛素样生长因子-I通过脐动脉PO（2）、胎龄和胎盘梗死/血肿的存在预测（模型的R（2）= 0.58，P <.0001），脐静脉胰岛素样生长因子结合蛋白-1通过脐静脉C-肽、脐动脉PO（2）、胎盘梗死/血肿（R（2）= 0.49，P <0.0001）。
结论
在早产胎儿中，循环中的胰岛素样生长因子-I与胎龄和宫内生长潜力相关，而胰岛素样生长因子结合蛋白-1仅与宫内生长潜力相关。PO（2）是胰岛素样生长因子-I和胰岛素样生长因子结合蛋白-1水平的决定因素;缺氧可能通过影响胰岛素样生长因子/胰岛素样生长因子结合蛋白轴来抑制胎儿生长。胰岛素是早产胎儿胰岛素样生长因子结合蛋白-1（而非胰岛素样生长因子-I）浓度的强有力决定因素。
OBJECTIVE
Our purpose was to evaluate which factors regulate insulin-like growth factor-I and insulin-like growth factor binding protein-1 concentrations in preterm fetuses.
STUDY DESIGN
We studied 76 singleton births between 25 and 36 weeks of gestation. Forty-nine pregnancies were complicated by hypertensive disease; 24 pregnancies were complicated by preterm labor or preterm rupture of membranes; and antenatal glucocorticoids were given in 49 pregnancies. Pathology reports showed infarct(s) or hematoma(s) in 31 of 69 placentas. We recorded blood gas values in umbilical artery and vein and measured glucose, C-peptide, and insulin-like growth factor-I and insulin-like growth factor binding protein-1 concentrations in umbilical vein.
RESULTS
Birth weight correlated with umbilical vein insulin-like growth factor-I (r = 0.68, P <.0001) and inversely with insulin-like growth factor binding protein-1 (r = -0.26, P =.02). Babies with birth weight of </=25th percentile had lower insulin-like growth factor-I but higher insulin-like growth factor binding protein-1 levels than babies at >25th percentile. Two-factor analysis of variance showed that umbilical vein insulin-like growth factor-I was determined by gestational age (P =.0004) and birth weight percentile (P <.0001), whereas insulin-like growth factor binding protein-1 was not affected by gestational age. Umbilical vein C-peptide was highly correlated with insulin-like growth factor binding protein-1 (r = -0.55, P <.0001), but not insulin-like growth factor-I, levels. Blood gas values in umbilical artery and vein, particularly umbilical artery PO (2), were correlated with umbilical vein insulin-like growth factor-I and insulin-like growth factor binding protein-1 (r = 0.51 and -0.48, respectively; P <.0001); changes in insulin-like growth factor-I and insulin-like growth factor binding protein-1 occurred at umbilical artery PO (2) <14.8 mm Hg. Multiple regression analysis showed that umbilical vein insulin-like growth factor-I was predicted by umbilical artery PO (2), gestational age, and the presence of placental infarcts/hematomas (R (2) of model = 0.58, P <.0001), and umbilical vein insulin-like growth factor binding protein-1 by umbilical vein C-peptide, umbilical artery PO (2), and placental infarcts/hematomas (R (2) = 0.49, P <.0001).
CONCLUSION
In the preterm fetus, circulating insulin-like growth factor-I is related to gestational age and the in utero growth potential, whereas insulin-like growth factor binding protein-1 is related only to the in utero growth potential. The PO (2) is a robust determinant of both insulin-like growth factor-I and insulin-like growth factor binding protein-1 levels; hypoxia may restrain fetal growth through its effects on the insulin-like growth factor/insulin-like growth factor binding protein axis. Insulin is a powerful determinant of insulin-like growth factor binding protein-1, but not insulin-like growth factor-I, concentrations in the preterm fetus.
地塞米松诱导的胎儿生长迟缓中胰岛素样生长因子 (IGF)、1 型 IGF 受体和 IGF 结合蛋白的基因表达。
影响因子：
4.8
作者：
Price,WA;Stiles,AD;Moats-Staats,BM;D'Ercole,AJ
通讯作者：
D'Ercole,AJ
DOI：
10.1073/pnas.95.17.10188
发表时间：
1998-08-18
影响因子：
11.1
作者：
Tazuke, SI;Mazure, NM;Giudice, LC
通讯作者：
Giudice, LC
足月胎儿脐动脉和静脉中的胰岛素样生长因子结合蛋白-1，有提示分娩过程中窘迫的迹象。
DOI：
10.1677/joe.0.1700585
发表时间：
2001
期刊：
The Journal of endocrinology
影响因子：
--
作者：
Verhaeghe,J;Billen,J;Giudice,LC
通讯作者：
Giudice,LC