Localized doxorubicin chemotherapy with a biopolymeric nanocarrier improves survival and reduces toxicity in xenografts of human breast cancer.
Localized doxorubicin chemotherapy with a biopolymeric nanocarrier improves survival and reduces toxicity in xenografts of human breast cancer.
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DOI：
10.1016/j.jconrel.2010.04.006
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发表时间：
2010-09-01
期刊：
影响因子：
--
通讯作者：
Forrest ML
中科院分区：
文献类型：
--
作者：
Cai S;Thati S;Bagby TR;Diab HM;Davies NM;Cohen MS;Forrest ML
转移性乳腺癌患者的五年存活率为27%，而局限型癌症患者的五年存活率为98%，在缺乏积极治疗的情况下，即使在淋巴结中存在少数癌细胞，即所谓的孤立肿瘤细胞或纳米转移瘤，也会显著增加复发的风险。因此，早期乳腺癌淋巴转移的诊断和治疗对患者的生存起着重要作用。在这里，我们展示了第一个描述阿霉素局部化疗到乳腺组织的输送系统。透明质酸-阿霉素纳米结合物在体外和体内均能在荷人乳腺癌移植瘤的啮齿动物乳腺组织中表现出缓释特性。此外，该结合物减少了剂量限制的心脏毒性，在正常组织中观察到的毒性最小。最后，这种结合物在体内显著抑制乳腺癌的进展，从而提高存活率。因此，使用纳米载体对乳房淋巴管进行局部化疗可能是治疗早期乳腺癌的一种改进策略。
Patients with metastatic breast cancer have a five-year survival rate of 27% compared to 98% for localized cancer, and the presence of even a few cancer cells in lymph nodes, known as isolated tumor cells or nanometastases, significantly increases the risk of relapse in the absence of aggressive treatment. Therefore, diagnosis and treatment of lymphatic metastases in early breast cancer plays an important role in patient survival. Here, we demonstrate the first description of a delivery system for localized doxorubicin chemotherapy to the breast tissue. The hyaluronan–doxorubicin nanoconjugate exhibits a sustained release characteristic in vitro and in vivo in the breast tissues of rodents bearing human breast cancer xenografts. In addition, the conjugate reduces dose-limiting cardiac toxicity with minimal toxicity observed in normal tissues. Finally, the conjugate dramatically inhibits breast cancer progression in vivo, leading to an increased survival rate. Thus, localized chemotherapy to the breast lymphatics with a nanocarrier may represent an improved strategy for treatment of early stage breast cancers.
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DOI：
10.1084/jem.180.1.53
发表时间：
1994-07-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Bartolazzi A;Peach R;Aruffo A;Stamenkovic I
通讯作者：
Stamenkovic I
影响因子：
50.5
作者：
O'Brien, MER;Wigler, N;Tendler, C
通讯作者：
Tendler, C
影响因子：
8.8
作者：
通讯作者：
--
影响因子：
11.5
作者：
Querzoli, Patrizia;Pedriali, Massimo;Nenci, Italo
通讯作者：
Nenci, Italo
影响因子：
4.5
作者：
Akima, K;Ito, H;Tatekawa, I
通讯作者：
Tatekawa, I