Assessment of functional cerebral laterality for language using magnetoencephalography.
Assessment of functional cerebral laterality for language using magnetoencephalography.
复制标题
使用脑磁图评估语言的功能性大脑偏侧性。
DOI：
10.1097/00004691-199807000-00009
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Papanicolaou,AC
中科院分区：
文献类型：
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作者：
Simos,PG;Breier,JI;Zouridakis,G;Papanicolaou,AC
本研究的目的是探讨脑磁图（MEG），一种非侵入性的功能脑成像技术，来评估大脑语言偏侧性的可行性。正常的头皮表面的磁通量测量与全头神经磁力计，而受试者（n= 16）进行了文字匹配和音调匹配的任务。半球和任务的数量上获得满意的等效电流偶极子（ECD）的解决方案的后期部分的反应，以文字和音调刺激的影响进行了检查。还计算了半球间ECD偏侧指数。在这两项任务中，令人满意的ECD解决方案定位于大脑外侧裂周皮质。在单词匹配任务中，16名受试者中有14名（87%）在左半球发现了更多的ECD，这一比例接近右撇子左半球优势的报道发生率。相似比例的受试者也表现出明显的不对称性，有利于左半球在语言任务相比，非语言任务的ECDs的数量。这些结果表明，MEG是一个有前途的工具，侧化评估。目前正在将基于脑磁图的功能不对称数据与侵入性术前程序（即，颈动脉内异戊巴比妥程序）进行比较。
The purpose of the study was to examine the feasibility of using magnetoencephalography (MEG), a noninvasive functional brain imaging technique, to assess cerebral laterality for language. The magnetic flux normal to the scalp surface was measured with a whole-head neuromagnetometer while subjects (n= 16) were engaged in a word-matching and a tone-matching task. The effect of hemisphere and task on the number of satisfactory equivalent current dipole (ECD) solutions obtained during the late portion of the responses to the word and tone stimuli was examined. An interhemispheric ECD laterality index was also computed. Satisfactory ECD solutions were localized in perisylvian cortices during both tasks. A greater number of ECDs was found in the left hemisphere in 14 (87%) of 16 of the subjects in the word-matching task, a proportion that approaches the reported incidence of left-hemisphere dominance among right-handers. A similar proportion of subjects also showed a clear asymmetry in the number of ECDs favoring the left hemisphere in the language task as compared to the nonlanguage task. These findings suggest that MEG is a promising tool for laterality assessment. Magnetoencephalography-based functional asymmetry data are currently being compared against invasive presurgical procedures (ie, intracarotid amobarbital procedure).