Virus-induced natural killer cell lysis of T cell subsets.
Virus-induced natural killer cell lysis of T cell subsets.
复制标题
DOI：
10.1016/j.virol.2019.10.003
复制
发表时间：
2020-01-02
期刊：
影响因子：
3.7
通讯作者：
Welsh RM
中科院分区：
文献类型：
--
作者：
Daniels KA;O'Donnell CL;Castonguay C;Strutt TM;McKinstry KK;Swain SL;Welsh RM
除了直接抗病毒活性之外，NK细胞还通过其对活化的CD4和CD8 T细胞的细胞溶解攻击来调节病毒发病机制。为了深入了解哪些分化的T细胞亚群是优选的NK靶标，将转基因T细胞在体外分化为Th0、Th1、Th2、Th17、Treg、Tc1和Tc2效应细胞，然后通过淋巴细胞性脉络丛脑膜炎病毒（LCMV）诱导的活化NK细胞的富集群体测试裂解。在体外和体内有一个明显的细胞毒性等级，Treg，Th17和Th2细胞更敏感，Th0和Th1细胞更耐药。体外与体内产生的T细胞之间的一些区别可以解释为1型干扰素诱导效应T细胞亚群上的1类组织相容性抗原。NK受体（NKR）缺陷小鼠和抗NKR抗体研究没有发现一个必要的NKR杀死，虽然可能有冗余。
In addition to direct anti-viral activity, NK cells regulate viral pathogenesis by virtue of their cytolytic attack on activated CD4 and CD8 T cells. To gain insight into which differentiated T cell subsets are preferred NK targets, transgenic T cells were differentiated in vitro into Th0, Th1, Th2, Th17, Treg, Tc1, and Tc2 effector cells and then tested for lysis by enriched populations of lymphocytic choriomeningitis virus (LCMV)-induced activated NK cells. There was a distinct hierarchy of cytotoxicity in vitro and in vivo, with Treg, Th17, and Th2 cells being more sensitive and Th0 and Th1 cells more resistant. Some distinctions between in vitro vs in vivo generated T cells were explainable by type 1 interferon induction of class 1 histocompatibility antigens on the effector T cell subsets. NK receptor (NKR)-deficient mice and anti-NKR antibody studies identified no one essential NKR for killing, though there could be redundancies.
登录
查看更多内容
影响因子：
3.7
作者：
Nielsen N;Ødum N;Ursø B;Lanier LL;Spee P
通讯作者：
Spee P
影响因子：
64.8
作者：
Bettelli, E;Carrier, YJ;Kuchroo, VK
通讯作者：
Kuchroo, VK
DOI：
10.1084/jem.20070041
发表时间：
2007-09-03
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
McKinstry KK;Golech S;Lee WH;Huston G;Weng NP;Swain SL
通讯作者：
Swain SL
影响因子：
16.6
作者：
Rydyznski, Carolyn;Daniels, Keith A.;Karmele, Erik P.;Brooks, Taylor R.;Mahl, Sarah E.;Moran, Michael T.;Li, Caimei;Sutiwisesak, Rujapak;Welsh, Raymond M.;Waggoner, Stephen N.
通讯作者：
Waggoner, Stephen N.
DOI：
10.4049/jimmunol.0801814
发表时间：
2009-03-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Hamada H;Garcia-Hernandez Mde L;Reome JB;Misra SK;Strutt TM;McKinstry KK;Cooper AM;Swain SL;Dutton RW
通讯作者：
Dutton RW