Cognitive improving and cerebral protective effects of acylated oligosaccharides in Polygala tenuifolia
Cognitive improving and cerebral protective effects of acylated oligosaccharides in Polygala tenuifolia
复制标题
DOI：
10.1248/bpb.27.1081
复制
发表时间：
2004-07-01
影响因子：
2
通讯作者：
Aburada, M
中科院分区：
文献类型：
--
作者：
Ikeya, Y;Takeda, S;Aburada, M
我们研究了远志根的认知改善和脑保护作用，远志是一种治疗健忘、神经衰弱、心悸、夜间排出和失眠的著名中药。薄荷叶皂苷B(1)是细叶连翘根中的一种酰化低聚糖，对氰化钾(KCN)所致小鼠缺氧有脑保护作用，可作为脑血管疾病的动物模型，对东莨菪碱所致大鼠被动回避作业能力减退也有改善作用。化合物1可显著增强氧化曲莫林诱发的小鼠震颤，提示其可通过增强胆碱能系统来改善东莨菪碱所致的被动回避反应障碍。这些发现表明化合物I具有改善认知和脑保护作用。
We studied the cognitive improving and cerebral protective constituents in the roots of Polygala tenuifolia WILLDENOW, a well-known Chinese traditional medicine prescribed for amnesia, neurasthenia, palpitation, noctural emission and insomnia. Tenuifoliside B (1), which is one of the acylated oligosaccharides in the roots of R tenuifolia, showed the cerebral protective effect on potassium cyanide (KCN)-induced anoxia in mice, widely used as an animal model for cerebrovascular disease, and also had an ameliorative effect on the scopolamine-induced impairment of performance in passive avoidance task in rats. Compound 1 significantly enhanced oxotremorine-induced tremors in mice, suggesting that it ameliorated the scopolamine-induced impairment of passive avoidance response by enhancing the cholinergic system. These findings show that compound I has cognitive improving and cerebral protective effects.