Association of Coffee Consumption With Total and Cause-Specific Mortality Among Nonwhite Populations.
Association of Coffee Consumption With Total and Cause-Specific Mortality Among Nonwhite Populations.
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DOI：
10.7326/m16-2472
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发表时间：
2017-08-15
影响因子：
39.2
通讯作者：
Setiawan VW
中科院分区：
文献类型：
--
作者：
Park SY;Freedman ND;Haiman CA;Le Marchand L;Wilkens LR;Setiawan VW
在前瞻性队列研究中，咖啡摄入与死亡风险降低有关；然而，关于非白人的数据却很稀少。
为了研究咖啡摄入与总体及特定病因死亡风险之间的关联。
多种族队列（MEC）是1993年至1996年间建立的一项基于人群的前瞻性队列研究。
地点在夏威夷以及加利福尼亚州洛杉矶。
招募了185855名非洲裔美国人、夏威夷原住民、日裔美国人、拉丁裔和白人，年龄在45岁至75岁之间。
研究结果是1993年至2012年间的总体死亡率和特定病因死亡率。通过一份经过验证的食物频率问卷在基线时评估咖啡摄入量。
在3195484人年的随访期间（平均随访16.2年），有58397名参与者死亡。与不喝咖啡相比，在对吸烟和其他潜在混杂因素进行调整后，咖啡摄入与较低的总体死亡率相关（每天1杯：风险比[HR]，0.88[95%置信区间，0.85 - 0.91]；每天2 - 3杯：HR，0.82[置信区间，0.79 - 0.86]；每天≥4杯：HR，0.82[置信区间，0.78 - 0.87]；趋势P值<0.001）。含咖啡因和不含咖啡因的咖啡趋势相似。在4个种族群体中观察到显著的负相关；在夏威夷原住民中这种关联未达到统计学意义。在从不吸烟者、较年轻的参与者（<55岁）以及那些之前未报告患有慢性疾病的人中也观察到负相关。在所研究的终点中，观察到与心脏病、癌症、呼吸系统疾病、中风、糖尿病和肾脏疾病导致的死亡呈负相关。
未测量的混杂因素和测量误差，尽管敏感性分析表明两者都不太可能影响结果。
在非洲裔美国人、日裔美国人、拉丁裔和白人中，较高的咖啡摄入量与较低的死亡风险相关。
美国国家癌症研究所
Coffee consumption has been associated with reduced risk for death in prospective cohort studies; however, data in nonwhites are sparse. To examine the association of coffee consumption with risk for total and cause-specific death. The MEC (Multiethnic Cohort), a prospective population-based cohort study established between 1993 and 1996. Hawaii and Los Angeles, California. 185 855 African Americans, Native Hawaiians, Japanese Americans, Latinos, and whites aged 45 to 75 years at recruitment. Outcomes were total and cause-specific mortality between 1993 and 2012. Coffee intake was assessed at baseline by means of a validated food-frequency questionnaire. 58 397 participants died during 3 195 484 person-years of follow-up (average follow-up, 16.2 years). Compared with drinking no coffee, coffee consumption was associated with lower total mortality after adjustment for smoking and other potential confounders (1 cup per day: hazard ratio [HR], 0.88 [95% CI, 0.85 to 0.91]; 2 to 3 cups per day: HR, 0.82 [CI, 0.79 to 0.86]; ≥4 cups per day: HR, 0.82 [CI, 0.78 to 0.87]; P for trend < 0.001). Trends were similar between caffeinated and decaffeinated coffee. Significant inverse associations were observed in 4 ethnic groups; the association in Native Hawaiians did not reach statistical significance. Inverse associations were also seen in never-smokers, younger participants (<55 years), and those who had not previously reported a chronic disease. Among examined end points, inverse associations were observed for deaths due to heart disease, cancer, respiratory disease, stroke, diabetes, and kidney disease. Unmeasured confounding and measurement error, although sensitivity analysis suggested that neither was likely to affect results. Higher consumption of coffee was associated with lower risk for death in African Americans, Japanese Americans, Latinos, and whites. National Cancer Institute.