Spatially- and temporally-restricted expression of meltrin α (ADAM12) and β (ADAM19) in mouse embryo
Spatially- and temporally-restricted expression of meltrin α (ADAM12) and β (ADAM19) in mouse embryo
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DOI：
10.1016/s0925-4773(98)00043-4
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发表时间：
1998-05-01
影响因子：
2.6
通讯作者：
Fujisawa-Sehara, A
中科院分区：
文献类型：
--
作者：
Kurisaki, T;Masuda, A;Fujisawa-Sehara, A
Meltrin beta（ADAM 19）是一种在小鼠肌细胞中表达的金属蛋白酶-去整合素，其全长cDNA的克隆揭示了Meltrin beta基因编码一种与meltrin alpha（ADAM 12）密切相关的膜蛋白，后者参与体外肌管形成。为了描述meltrin alpha和beta的功能，我们研究了它们在胚胎发生过程中转录物的表达模式。meltrin alpha基因在产生骨骼肌、骨骼和内脏器官的浓缩间充质细胞中被激活。相比之下，Meltrin β mRNA在颅面神经节和背根神经节以及脊髓腹角中显著表达，其中外周神经元细胞谱系分化。心脏、骨骼肌、肠和肺也瞬时表达meltrin β mRNA。尽管meltrin α和β转录物在胚胎发生过程中表现出不同的表达模式，但这两种基因主要在来源于中胚层和外胚层的间充质细胞中活化。(C)1998爱思唯尔科学爱尔兰有限公司保留所有权利。
The cloning of the full-length cDNA encoding meltrin beta (ADAM19), one of the metalloprotease-disintegrins expressed in mouse myogenic cells, revealed that the meltrin beta gene encodes a membrane protein closely related to meltrin alpha (ADAM12) which participates in myotube formation in vitro. To delineate the functions of meltrin alpha and beta, we examined the expression patterns of their transcripts during embryogenesis, The meltrin alpha gene is activated in condensed mesenchymal cells that give rise to skeletal muscle, bones and visceral organs. Meltrin beta mRNA, in contrast, is markedly expressed in craniofacial and dorsal root ganglia and ventral horns of the spinal cord, where peripheral neuronal cell lineages differentiate. Heart, skeletal muscle, intestine and lung also express meltrin beta mRNA transiently. Although the meltrin alpha and beta transcripts exhibit distinct expression patterns during embryogenesis, both genes are mainly activated in mesenchymal cells that are derived from both mesoderm and ectoderm. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.