Epileptogenesis in immature rats following recurrent status epilepticus
Epileptogenesis in immature rats following recurrent status epilepticus
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DOI：
10.1016/s0165-0173(99)00089-2
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发表时间：
2000-04-01
影响因子：
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通讯作者：
Cavalheiro, EA
中科院分区：
文献类型：
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作者：
dos Santos, NF;Arida, RM;Cavalheiro, EA
强有力的证据表明，儿童时期的癫痫持续状态(SE)与癫痫的后期发展有关。毛果芸香碱诱导的SE仅在生后18天后才出现自发性癫痫发作。我们研究了在出生后第7天、第8天和第9天连续3次毛果芸香碱诱发癫痫发作的可能性，以诱导成年后的行为、脑电和组织学改变。动物还接受了行为学测试(抑制性跳台回避、Skinner盒、旋转杆、开阔视野和高架正迷宫)。在30日龄、60日龄和90日龄时的脑电记录显示，在海马区和皮质中同时出现了几次棘波和/或多棘波。在整个观察期间(120天)，仅观察到3次孤立的自发性癫痫发作。连续三次SE的长期效果包括增加自发探索活动，学习障碍，以及在P60测试时减少焦虑。我们的发现为出生后7-9天反复发作的SE后成人生活中的脑电变化和认知障碍提供了证据。(C)2000 Elsevier Science B.V.保留所有权利。
Strong evidences link; status epilepticus (SE) in childhood with the later development of epilepsy. Pilocarpine-induced SE in developing rats leads to late appearance of spontaneous epileptic seizures only when SE is induced after the 18th day of life. We examined the possibility that 3 consecutive episodes of pilocarpine-induced SE on postnatal days 7, 8 and 9 could induce behavioral, electrographic and histological epileptic changes in adult life. The animals also underwent behavioral tests (inhibitory step-down avoidance, skinner box, rota-rod, open field and elevated plus-maze). EEG recordings made at the age of 30, 60 and 90 days showed the occurrence of several episodes of spikes and/or polyspikes appearing simultaneously in hippocampus and cortex. Only three isolated spontaneous seizures were observed during the whole period of observation (120 days). The long-term effects of three consecutive episodes of SE include increased spontaneous exploratory activity, learning impairment, and reduced anxiety when tested on P60. Our findings provide evidence for EEG changes and cognitive deficits in adult life following recurrent SE on postnatal days 7-9. (C) 2000 Elsevier Science B.V. All rights reserved.