Involvement of the dorsolateral prefrontal cortex of monkeys in visuospatial target selection
Involvement of the dorsolateral prefrontal cortex of monkeys in visuospatial target selection
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DOI：
10.1152/jn.00148.2002
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发表时间：
2003-01-01
影响因子：
2.5
通讯作者：
Sawaguchi, T
中科院分区：
文献类型：
--
作者：
Iba, M;Sawaguchi, T
要检查参与的背外侧前额叶皮层（PFC）在视觉空间的目标选择，我们诱导本地，可逆的失活蝇蕈醇在不同的网站在背外侧PFC的两只恒河猴，而他们进行眼视觉搜索（OVS）和眼检测（OD）的任务。OVS任务要求受试者从干扰物中选择目标刺激，并对目标位置进行扫视（正确的性能需要目标选择），而OD任务只需要对目标进行扫视（正确的性能不需要目标选择）。蝇蕈醇（5杯，1穆尔）的背外侧PFC的局部注射诱导的特定赤字在OVS任务，但在OD任务。在OVS任务的赤字的特点是由一些（主要是少数）特定的目标位置，以及在大多数情况下，视觉搜索所需的时间延长的扫视无序。蝇蕈醇作用的靶点偏向对侧视野。此外，具有“弹出”和“非弹出”条件的OVS任务类似地被蝇蕈醇注射损害。这些结果表明，背外侧PFC在视觉空间中的目标选择中发挥作用，以指导目标导向的运动行为，并且特定的位点参与特定视觉空间坐标的目标选择。此外，背外侧PFC的这一功能似乎涉及自上而下（主动）和自下而上（被动）的目标选择/选择性注意过程，以控制干扰信息（干扰物）。
To examine the involvement of the dorsolateral prefrontal cortex (PFC) in visuospatial target selection, we induced local, reversible inactivation with muscimol at various sites in the dorsolateral PFC of two rhesus monkeys while they performed oculomotor visual search (OVS) and oculomotor detection (OD) tasks. The OVS task required the subject to select a target stimulus from among distractors and to make a saccade to the target location (target selection was required for correct performance), whereas the OD task only required a saccade to the target (target selection was not required for correct performance). The local injection of muscimol (5 mug, 1 mul) into the dorsolateral PFC induced a specific deficit in the OVS task but not in the OD task. The deficit in the OVS task was characterized by the disordering of saccades for some (mostly a few) particular target locations as well as by prolongation of the time required for the visual search in most cases. The target locations affected by muscimol were biased to the contralateral visual field. Further, the OVS task with "pop-out" and "non-pop-out" conditions was similarly impaired by muscimol injection. These results suggest that the dorsolateral PFC plays a role in target selection in visual space to guide goal-directed motor acts and particular sites are involved in target selection for a particular visuospatial coordinate. Further, this function of the dorsolateral PFC appears to involve both top-down (active) and bottom-up (passive) target-selection/selective attention processes to control interfering information (distractors).