Reduction of the number of major representative allergens: from clinical testing to 3-dimensional structures.
Reduction of the number of major representative allergens: from clinical testing to 3-dimensional structures.
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减少主要代表性过敏原的数量：从临床测试到三维结构
DOI：
10.1155/2014/291618
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发表时间：
2014
影响因子：
4.6
通讯作者：
Sun B
中科院分区：
文献类型：
--
作者：
He Y;Liu X;Huang Y;Zou Z;Chen H;Lai H;Zhang L;Wu Q;Zhang J;Wang S;Zhang J;Tao A;Sun B
已经积累了大量的过敏原序列数据，因此在进行诊断性过敏试验和免疫治疗时，使特异性过敏原蛋白的鉴定变得复杂。本研究旨在对过敏原的重要性/效力进行排序，从而从逻辑上减少过敏原和/或过敏原源的数量。对3335例过敏患者皮内检测的62种过敏原源进行meta分析发现，在中国南方地区，螨虫、芝麻、刺苋菜、铜绿假单胞菌和室内灰尘对62种过敏原源的阳性反应占88.0% ~ 100%。网站获得的过敏原数据和过敏原家族特征肽的Kolmogorov-Smironov测试结果表明，世界各地实验室的过敏原研究已经在许多相同物种上平行进行。主要过敏原减少到21个具有代表性的过敏原，并进一步分为7个结构类，每个结构类含有相似的结构成分。因此，本研究将众多的过敏原来源和主要过敏原浓缩为较少的主要代表性过敏原，从而允许在进行全面的过敏原检测和免疫治疗时使用较少数量的过敏原。
Vast amounts of allergen sequence data have been accumulated, thus complicating the identification of specific allergenic proteins when performing diagnostic allergy tests and immunotherapy. This study aims to rank the importance/potency of the allergens so as to logically reduce the number of allergens and/or allergenic sources. Meta-analysis of 62 allergenic sources used for intradermal testing on 3,335 allergic patients demonstrated that in southern China, mite, sesame, spiny amaranth, Pseudomonas aeruginosa, and house dust account for 88.0% to 100% of the observed positive reactions to the 62 types of allergenic sources tested. The Kolmogorov-Smironov Test results of the website-obtained allergen data and allergen family featured peptides suggested that allergen research in laboratories worldwide has been conducted in parallel on many of the same species. The major allergens were reduced to 21 representative allergens, which were further divided into seven structural classes, each of which contains similar structural components. This study therefore has condensed numerous allergenic sources and major allergens into fewer major representative ones, thus allowing for the use of a smaller number of allergens when conducting comprehensive allergen testing and immunotherapy treatments.