Neonatal adenovirus pneumonia.
Neonatal adenovirus pneumonia.
复制标题
新生儿腺病毒肺炎。
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
W. Aw
中科院分区：
文献类型：
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作者：
Green Wr;W. Aw
一名患有透明膜疾病的 13 天早产儿被发现肺细胞发生改变，表明病毒感染。肺细胞具有嗜碱性或嗜酸性的核包涵体，细胞质保存不良。将 1 型和 2 型单纯疱疹病毒核衣壳特异的单克隆抗体应用于福尔马林固定的肺切片，没有反应。肺组织的电子显微镜显示了腺病毒的特征性晶体阵列。有记录的腺病毒感染虽然在婴儿期和儿童期很常见，但在新生儿期很少见。病毒感染的光镜诊断缺乏特异性，腺病毒感染可能被误诊。除了更常见的单纯疱疹病毒和巨细胞病毒之外，新生儿肺部很容易受到病毒的感染，因此应尽可能使用病毒培养、免疫细胞化学或电子显微镜检查。
A 13-day-old premature infant with hyaline membrane disease was found to have altered pneumocytes, suggesting viral infection. Pneumocytes had nuclear inclusions that were basophilic or eosinophilic with poorly preserved cytoplasm. Monoclonal antibodies specific for the nucleocapsid of herpes simplex virus types 1 and 2 applied to formalin-fixed lung sections were nonreactive. Electron microscopy of lung tissue showed the characteristic crystalline arrays of adenovirus. Documented adenovirus infection, while common in infancy and childhood, is rare in the neonatal period. Light microscopic diagnosis of viral infection lacks specificity, and adenovirus infection may be misdiagnosed. The neonatal lung is vulnerable to viruses other than the more commonly found herpes simplex and cytomegalovirus, and viral culture, immunocytochemistry, or electron microscopy should be used when possible.