Circadian regulation of physiology by disordered protein-protein interactions
Circadian regulation of physiology by disordered protein-protein interactions
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DOI：
10.1016/j.sbi.2023.102743
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发表时间：
2023-12-13
影响因子：
6.8
通讯作者：
Hurley，Jennifer M.
中科院分区：
文献类型：
--
作者：
Sutton，Lucas B.;Hurley，Jennifer M.
细胞生物钟是在生命领域协调生理学与昼夜周期的分子计时器，广泛受到无序蛋白质相互作用的调节。在这里，我们回顾了粗糙脉孢菌（N. crassa）生物钟中无序-无序蛋白质相互作用，粗糙脉孢菌是一种丝状真菌，是高等真核生物生物钟的模式生物。我们重点关注本质上无序的核心负臂蛋白频率（FRQ）、构成转录-翻译反馈环的其他蛋白质以及控制输出的蛋白质之间的相互作用。我们将该模型与其他真核生物钟模型进行了比较和对比，说明蛋白质紊乱是维持跨物种生物钟的保守且重要的机制。
Cellular circadian clocks, the molecular timers that coordinate physiology to the day/night cycle across the domains of life, are widely regulated by disordereddisordered protein interactions. Here, we review the disordered-disordered protein interactions in the circadian clock of Neurospora crassa (N. crassa), a filamentous fungus which is a model organism for clocks in higher eukaryotes. We focus on what is known about the interactions between the intrinsically disordered core negative arm protein FREQUENCEY (FRQ), the other proteins comprising the transcription-translation feedback loop, and the proteins that control output. We compare and contrast this model with other models of eukaryotic clocks, illustrating that protein disorder is a conserved and essential mechanism in the maintenance of circadian clock across species.