NEAT expression is associated with tumor recurrence and unfavorable prognosis in colorectal cancer.
NEAT expression is associated with tumor recurrence and unfavorable prognosis in colorectal cancer.
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NEAT 表达与结直肠癌肿瘤复发和不良预后相关
DOI：
10.18632/oncotarget.4737
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发表时间：
2015-09-29
期刊：
影响因子：
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通讯作者：
Li J
中科院分区：
文献类型：
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作者：
Li Y;Li Y;Chen W;He F;Tan Z;Zheng J;Wang W;Zhao Q;Li J
最近发现长非编码RNA（lncRNA）与包括癌症在内的多种疾病有关。 NEAT1 是最近发现的一种 lncRNA，其在人类恶性肿瘤中的功能很大程度上未知。在本研究中，我们调查了239例临床结直肠癌标本和匹配的正常组织中NEAT1的表达。采用统计方法分析NEAT1与患者临床特征、无病生存和总生存的关系。结果显示，与正常人相比，结直肠癌中NEAT1的表达上调率为72.0%（172/239），且与肿瘤的分化、侵袭、转移和TNM分期相关。 Kaplan-Meier分析证明NEAT1与结直肠癌患者的无病生存率和总生存率相关，NEAT1高表达的患者往往预后不良。此外，cox 比例风险分析表明，NEAT1 高表达是不良结果的独立预后标志。这些结果首次证明NEAT1在结直肠癌中的表达可能在结直肠癌的分化、侵袭和转移中发挥致癌作用。也证明NEAT1可以作为结直肠癌肿瘤复发和预后的指标。
Long noncoding RNAs (lncRNAs) have recently been identified to be involved in various diseases including cancer. NEAT1 is a recently identified lncRNA with its function largely unknown in human malignancy. In the present study, we investigated NEAT1 expression in 239 cases of clinical colorectal cancer specimens and matched normal tissues. Statistical methods were utilized to analyze the association of NEAT1 with clinical features, disease-free and overall survival of patients. Results showed that NEAT1 expression in colorectal cancer was up-regulated in 72.0% (172/239) cases compared with corresponding normal counterparts, and related to tumor differentiation, invasion, metastasis and TNM stage. Kaplan-Meier analysis proved that NEAT1 was associated with both disease-free survival and overall survival of patients with colorectal cancer that patients with high NEAT1 expression tend to have unfavorable outcome. Moreover, cox’s proportional hazards analysis showed that high NEAT1 expression was an independent prognostic marker of poor outcome. These results provided the first evidence that the expression of NEAT1 in colorectal cancer may play an oncogenic role in colorectal cancer differentiation, invasion and metastasis. It also proved that NEAT1 may serve as an indicator of tumor recurrence and prognosis of colorectal cancer.