Distinct roles for distal-less genes Dlx3 and Dlx5 in regulating ectodermal development in Xenopus
Distinct roles for distal-less genes Dlx3 and Dlx5 in regulating ectodermal development in Xenopus
复制标题
DOI：
10.1002/mrd.1095
复制
发表时间：
2001-11-01
影响因子：
2.5
通讯作者：
Sargent, TD
中科院分区：
文献类型：
--
作者：
Luo, T;Matsuo-Takasaki, M;Sargent, TD
果蝇模式形成同源结构域基因Distal-less在脊椎动物中有6个或6个以上的拷贝，其中Dlx 3和Dlx 5具有广泛的序列同源性和相似但不同的表达模式，提示这两个因子可能具有丰富的发育功能。在这里，我们表明，在非洲爪蟾胚胎发生的最早阶段，有Dlx 3和Dlx 5的表达之间的显着差异，这与不同的功能，在神经嵴和神经板边界的限制，分别。(C)2001 Wiley-Liss，Inc.
In vertebrates, there are six or more copies of genes related to the Drosophila pattern formation homeodomain gene Distal-less. Among this family, Dlx3 and Dlx5 share extensive sequence homology and have similar, but distinctive, expression patterns, suggesting that these two factors may have substantially redundant developmental functions. Here we show that at the earliest phases of embryogenesis in Xenopus, there are significant differences between Dlx3 and Dlx5 expression and that this correlates with different functions in the restriction of neural crest and neural plate boundaries, respectively. (C) 2001 Wiley-Liss, Inc.