Electrophysiological markers of covert face recognition in developmental prosopagnosia
Electrophysiological markers of covert face recognition in developmental prosopagnosia
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DOI：
10.1093/brain/awr347
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发表时间：
2012-02-01
期刊：
影响因子：
14.5
通讯作者：
Duchaine, Bradley
中科院分区：
文献类型：
--
作者：
Eimer, Martin;Gosling, Angela;Duchaine, Bradley
为了研究患有发育性面部失认症的个体隐性面部识别的存在和神经基础，我们测试了一组 12 名患有发育性面部失认症的参与者，任务要求他们判断连续出现的著名或非著名面孔的熟悉程度。在任务执行过程中记录脑电图，并计算已识别的著名面孔、未识别的著名面孔和非著名面孔的事件相关脑电位。在六名患有发育性面容失认症的个体中，未被识别的著名面孔触发了枕颞 N250 成分，这被认为反映了已知个体面孔所存储的视觉记忆痕迹的激活。与 N250 相比，P600f 组件与面部身份处理的后期语义阶段相关，不会由未识别的名人面孔触发。在少数试验中，患有发育性面容失认症的参与者将著名面孔分类为已知或熟悉的，而获得的外显面部识别与事件相关的潜在相关性与之前在具有完整面部识别能力的参与者中发现的效果相似，这表明患有发育性面容失认症的个体的面部识别机制与未受损个体的面部识别机制没有本质上的不同。总体而言，这些与事件相关的潜在结果为发育性面盲症中隐蔽面部识别提供了第一个神经生理学证据，并表明这种现象是由于完整的身份特异性视觉记忆痕迹与后来的语义面部处理阶段之间的脱节联系造成的。它们还意味着，激活存储的熟悉面孔的视觉表征不足以进行有意识的显式面孔识别。
To study the existence and neural basis of covert face recognition in individuals with developmental prosopagnosia, we tested a group of 12 participants with developmental prosopagnosia in a task that required them to judge the familiarity of successively presented famous or non-famous faces. Electroencephalography was recorded during task performance, and event-related brain potentials were computed for recognized famous faces, non-recognized famous faces and non-famous faces. In six individuals with developmental prosopagnosia, non-recognized famous faces triggered an occipito-temporal N250 component, which is thought to reflect the activation of stored visual memory traces of known individual faces. In contrast to the N250, the P600f component, which is linked to late semantic stages of face identity processing, was not triggered by non-recognized famous faces. Event-related potential correlates of explicit face recognition obtained on those few trials where participants with developmental prosopagnosia classified famous faces as known or familiar, were similar to the effects previously found in participants with intact face recognition abilities, suggesting that face recognition mechanisms in individuals with developmental prosopagnosia are not qualitatively different from that of unimpaired individuals. Overall, these event-related potential results provide the first neurophysiological evidence for covert face recognition in developmental prosopagnosia, and suggest this phenomenon results from disconnected links between intact identity-specific visual memory traces and later semantic face processing stages. They also imply that the activation of stored visual representations of familiar faces is not sufficient for conscious explicit face recognition.