Changes in opioid and other analgesic use 1995-2010: Repeated cross-sectional analysis of dispensed prescribing for a large geographical population in Scotland
Changes in opioid and other analgesic use 1995-2010: Repeated cross-sectional analysis of dispensed prescribing for a large geographical population in Scotland
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DOI：
10.1002/ejp.520
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发表时间：
2015-01-01
影响因子：
3.6
通讯作者：
Guthrie, B.
中科院分区：
文献类型：
--
作者：
Ruscitto, A.;Smith, B. H.;Guthrie, B.
背景尽管最近对止痛药处方率的增加感到担忧，但缺乏详细的流行病学研究。我们确定并描述了1995年3月31日至1999年12月31日期间苏格兰泰赛德地区社区处方模式的变化。（n= 301，020）和2010年3月31日（n= 311，881）.方法重复的横断面分析病人水平的人口数据分发止痛药，分层的社会人口变量; Logistic回归分析2010年强阿片类药物处方的相关因素。结果2010年处方任何镇痛药的人群比例（17.9%）较1995年（15.7%）有所增加。这一增加在药物类别之间并不相等，对乙酰氨基酚、阿片类和加巴喷丁/普瑞巴林显示增加，但其他药物显示减少。2010年，弱阿片类药物的分发较少（8.2%对8.4%），但强阿片类药物的分发增加了18倍（3.6%对0.2%），其中吗啡、芬太尼或羟考酮增加了5倍（0.75%对0.15%）。接受更多非镇痛药物的患者（如果分配>14种非镇痛药物，则比值比为20.7
BackgroundDespite recent concerns about increasing rates of analgesic prescribing, detailed epidemiological studies are lacking. We identified and described changes in the pattern of community-dispensed prescriptions to the Tayside population, Scotland, between 31st March 1995 (n=301,020) and 31st March 2010 (n=311,881).MethodsRepeated cross-sectional analysis of patient-level population data on dispensed analgesics, stratified by sociodemographic variables; logistic regression to identify factors associated with strong opioid dispensing in 2010.ResultsThe proportion of people currently dispensed any analgesic increased in 2010 (17.9%) compared with 1995 (15.7%). This increase was not equal across drug classes, with paracetamol, opioids and gabapentin/pregabalin showing an increase, but others showing a decrease. Weak opioids were less commonly dispensed in 2010 (8.2% vs. 8.4%) but dispensing of strong opioids increased 18-fold (3.6% vs. 0.2%), including a five-fold increase of morphine, fentanyl or oxycodone (0.75% vs. 0.15%). People receiving more non-analgesic drugs (odds ratio 20.7 if dispensed >14 non-analgesic medications vs. those dispensed