Opportunities for CAR-T Cell Immunotherapy in HIV Cure.
Opportunities for CAR-T Cell Immunotherapy in HIV Cure.
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DOI：
10.3390/v15030789
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发表时间：
2023-03-19
期刊：
影响因子：
--
通讯作者：
Salgado M
中科院分区：
文献类型：
--
作者：
Campos-Gonzalez G;Martinez-Picado J;Velasco-Hernandez T;Salgado M
嵌合抗原受体（CAR）技术在血液恶性肿瘤领域产生了巨大的影响，并正在成为许多类型白血病的成熟疗法。近几十年来，人们一直在努力证明CAR-T细胞有潜力作为一种治疗方法，以实现对人类免疫缺陷病毒（HIV）感染的灭菌治疗。然而，将这种技术转化为HIV方案并不容易，因为沿着许多挑战已经出现，阻碍了CAR-T细胞作为公认疗法的巩固。在这里，我们回顾了CAR-T细胞的起源和发展，描述了CAR-T细胞疗法与其他疗法相比的优势，并描述了目前在HIV领域应用该技术所面临的主要障碍，特别是病毒逃逸，CAR-T细胞感染性和隐藏水库的可及性。尽管如此，在临床试验中成功解决其中一些问题的可喜结果表明，CAR-T细胞作为一种综合疗法具有光明的前景。
Chimeric antigen receptor (CAR) technology is having a huge impact in the blood malignancy field and is becoming a well-established therapy for many types of leukaemia. In recent decades, efforts have been made to demonstrate that CAR-T cells have potential as a therapy to achieve a sterilizing cure for human immunodeficiency virus (HIV) infection. However, translation of this technology to the HIV scenario has not been easy, as many challenges have appeared along the way that hinder the consolidation of CAR-T cells as a putative therapy. Here, we review the origin and development of CAR-T cells, describe the advantages of CAR-T cell therapy in comparison with other therapies, and describe the major obstacles currently faced regarding application of this technology in the HIV field, specifically, viral escape, CAR-T cell infectivity, and accessibility to hidden reservoirs. Nonetheless, promising results in successfully tackling some of these issues that have been obtained in clinical trials suggest a bright future for CAR-T cells as a consolidated therapy.
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