Mapping the gene ontology into the unified medical language system
Mapping the gene ontology into the unified medical language system
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DOI：
10.1002/cfg.407
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发表时间：
2004-06-01
影响因子：
--
通讯作者：
McCray, AT
中科院分区：
文献类型：
--
作者：
Lomax, J;McCray, AT
我们最近映射的基因本体论（GO），由基因本体论联盟开发，到国家医学图书馆的统一医学语言系统（UMLS）。GO是为了在基因组数据库中注释基因产物而开发的，而UMLS是作为整合大量不同术语的框架而开发的，主要是为了更好地访问生物医学信息源。GO到UMLS的映射突出了两个术语系统中的问题。在UMLS和GO团队之间进行了一些初步的探索和讨论之后，GO与UMLS集成在一起。总体而言，共有23%的GO术语直接匹配（3%）或链接（20%）到现有的UMLS概念。所有GO术语现在都有相应的官方UMLS概念，整个词汇表可以通过基于Web的UMLS知识源服务器获得。基因本体论的映射，其重点是在分子水平上的结构，过程和功能，现有的广泛覆盖UMLS应有助于连接的语言和临床医学的语言和实践的基因组学的做法。版权所有（C）2004约翰威利父子有限公司。
We have recently mapped the Gene Ontology (GO), developed by the Gene Ontology Consortium, into the National Library of Medicine's Unified Medical Language System (UMLS). GO has been developed for the purpose of annotating gene products in genome databases, and the UMLS has been developed as a framework for integrating large numbers of disparate terminologies, primarily for the purpose of providing better access to biomedical information sources. The mapping of GO to UMLS highlighted issues in both terminology systems. After some initial explorations and discussions between the UMLS and GO teams, the GO was integrated with the UMLS. Overall, a total of 23% of the GO terms either matched directly (3%) or linked (20%) to existing UMLS concepts. All GO terms now have a corresponding, official UMLS concept, and the entire vocabulary is available through the web-based UMLS Knowledge Source Server. The mapping of the Gene Ontology, with its focus on structures, processes and functions at the molecular level, to the existing broad coverage UMLS should contribute to linking the language and practices of clinical medicine to the language and practices of genomics. Copyright (C) 2004 John Wiley Sons, Ltd.