Relationship between smoking, white blood cell count and metabolic syndrome in Japanese women
Relationship between smoking, white blood cell count and metabolic syndrome in Japanese women
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DOI：
10.1016/j.diabres.2007.02.009
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发表时间：
2007-10-01
影响因子：
5.1
通讯作者：
Yamakado, Minoru
中科院分区：
文献类型：
--
作者：
Ishizaka, Nobukazu;Ishizaka, Yuko;Yamakado, Minoru
我们发现吸烟会增加白细胞计数，而白细胞计数增加的人更容易患代谢综合征。我们调查了在女性中是否也能观察到类似的关系。我们分析了16383名日本女性的数据，她们接受了一般健康检查。年龄校正logistic回归分析显示，当前吸烟与白细胞计数最高四分位数呈正相关，优势比为2.40 （95% CI: 2.16-2.68, P < 0.0001）。白细胞计数与代谢综合征呈分级相关。另一方面，根据白细胞四分位数将个体细分为组后，当前吸烟与代谢综合征之间的关联不再显著。这些数据共同表明，当前吸烟与代谢综合征之间的联系在很大程度上被某些因素所混淆，这些因素会增加日本女性和男性的循环白细胞计数。2007爱思唯尔爱尔兰有限公司版权所有。
We found that cigarette smoking increased white blood cell count, and individuals which increased white blood cell count more likely to have metabolic syndrome in Japanese men. We investigated whether similar relationship can be observed also in women. We analyzed the data from 16,383 Japanese women who underwent general health screening. Age-adjusted logistic regression analysis showed that current smoking was positively associated with a highest white blood cell count quartile with an odds ratio of 2.40 (95% CI: 2.16-2.68, P < 0.0001). The white blood cell count showed a graded association with metabolic syndrome. On the other hand, the association between current smoking and metabolic syndrome was no longer significant after subdividing the individuals into groups according to the white blood cell quartile. These data collectively suggested that the association between current smoking and metabolic syndrome is heavily confounded by certain factors that increase the circulating white blood cell count in Japanese women, as in men. (C) 2007 Elsevier Ireland Ltd. All rights reserved.