Impact of age on the short-term postoperative outcome of patients undergoing surgery for colorectal carcinoma
Impact of age on the short-term postoperative outcome of patients undergoing surgery for colorectal carcinoma
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DOI：
10.1007/s003840100344
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发表时间：
2002-05-01
影响因子：
2.8
通讯作者：
Lippert, H
中科院分区：
文献类型：
--
作者：
Marusch, F;Koch, A;Lippert, H
背景：患者年龄对肿瘤手术术后短期疗效有决定性影响。患者和方法：这项前瞻性多中心研究纳入了1999年75家德国医院和3756例接受治疗的患者：65岁以下1447例，65-79岁1847例，80岁以上458例。结果：老年组广泛、局部肿瘤比例（UICC 11期分别为25.9%、28.4%、36.1%）明显高于老年组，三组在手术率（98.8%、98.6%、96.5%）、切除率（94.2%、93.2%、83.9%）、术后一般并发症（21.5%、28.6%、41.2%）、发病率（36.5%、42.6%、50.0%）、死亡率（2.7%、6.6%、11.8%）等方面差异均有统计学意义。结论：在老年人中，肿瘤局部进展，但不转移。都在意料之中。随着年龄的增长，术后发病率和死亡率的增加是由于一般术后并发症的增加。高龄结直肠癌患者的手术与术中或特定术后并发症的增加无关。
Background: Patient age has a decisive impact on the short-term postoperative results in surgery for carcinoma. Patients and methods: This prospective multicenter study involved 75 German hospitals and 3756 patients undergoing treatment in 1999: 1447 aged under 65 years, 1847 aged 65-79 years, and 458 aged over 80 years. Results: In the oldest patient group, there was a significantly higher proportion of extensive, localized tumors (UICC stage 11: 25.9%, 28.4%, and 36.1%, respectively) and significant differences were found among the three groups in operation rates (98.8%, 98.6%, and 96.5%), resection rate (94.2%, 93.2%, and 83.9%), general postoperative complications (21.5%, 28.6%, and 41.2%), morbidity (36.5%, 42.6%, and 50.0%) and mortality (2.7%, 6.6%, and 11.8%). Conclusion: In the elderly, locally advanced tumors, but not metastasizing tumors. are to be expected. The increase in postoperative morbidity and mortality rates with increasing age was due to the increase in general postoperative complications. Surgery for colorectal carcinoma in patients of advanced age is not associated with any increase in intraoperative or specific postoperative complications.