Dual-head gamma camera 2-[fluorine-18]-fluoro-2-deoxy-d-glucose positron emission tomography in oncological patients: effects of non-uniform attenuation correction on lesion detection
Dual-head gamma camera 2-[fluorine-18]-fluoro-2-deoxy-d-glucose positron emission tomography in oncological patients: effects of non-uniform attenuation correction on lesion detection
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双头伽玛相机 2-[氟-18]-氟-2-脱氧-d-葡萄糖正电子发射断层扫描在肿瘤患者中的应用：非均匀衰减校正对病变检测的影响
DOI：
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
U. Buell
中科院分区：
文献类型：
--
作者：
M. Zimny;H. Kaiser;U. Cremerius;P. Reinartz;M. Schreckenberger;O. Sabri;U. Buell
抽象。本研究的目的是评估双头符合伽马相机（DH-PET）配备单光子传输2-[氟-18]-氟-2-脱氧-d-葡萄糖（FDG）成像肿瘤患者。45例已知或疑似恶性肿瘤的患者，计划进行正电子发射断层扫描（PET）扫描，首先使用专用环形PET进行研究，随后使用DH-PET。所有患者均接受了测量衰减校正，使用锗-68棒源进行环形PET，使用铯-137源进行DH-PET。静脉注射235±42 MBq FDG后64±17 min开始环形PET发射扫描。静脉注射FDG后160±32分钟进行DH-PET发射。对环形PET和DH-PET重建衰减校正和非衰减校正图像。由三名对临床数据和常规成像结果不知情的观察者独立评价图像集。作为参考标准的衰减校正的环形PET显示了118个病灶，非衰减校正的环形PET显示了113个病灶（96%），衰减校正的DH-PET和非衰减校正的DH-PET分别显示了101个（86%）和84个（71%）病灶（P<0.05）。对于直径>20 mm的病灶，衰减校正和非衰减校正DH-PET的病灶检出率几乎相似，而对于直径≤ 20 mm的病灶，衰减校正DH-PET的检出率从60%提高到80%（P<0.01）。一项基于患者的分析显示，42例（93%）、36例（80%）和31例（69%）患者的非衰减校正环形PET、衰减校正DH-PET和非衰减校正DH-PET与衰减校正环形PET的结果一致。差异可能分别影响了2例（4%）、6例（13%）和10例（22%）患者的治疗。总之，测量的衰减校正显著提高了DH-PET的病变检测能力。通过测量衰减校正，DH-PET的诊断性能更接近专用环形PET的诊断性能。
Abstract. The purpose of this study was to evaluate a dual head coincidence gamma camera (DH-PET) equipped with single-photon transmission for 2-[fluorine-18]-fluoro-2-deoxy-d-glucose (FDG) imaging in oncological patients. Forty-five patients with known or suspected malignancies, scheduled for a positron emission tomography (PET) scan, were first studied with a dedicated ring PET and subsequently with DH-PET. All patients underwent measured attenuation correction using germanium-68 rod sources for ring PET and caesium-137 sources for DH-PET. Ring PET emission scan was started 64±17 min after intravenous administration of 235±42 MBq FDG. DH-PET emission followed 160±32 min after i.v. FDG. Attenuation-corrected and non-attenuation-corrected images were reconstructed for ring PET and DH-PET. The image sets were evaluated independently by three observers blinded to clinical data and to results of conventional imaging. Attenuation-corrected ring PET as the standard of reference depicted 118 lesions, non-attenuation-corrected ring PET 113 (96%) lesions, and attenuation-corrected DH-PET and non-attenuation-corrected DH-PET, 101 (86%) and 84 (71%) lesions, respectively (P<0.05). The lesion detection rate of attenuation-corrected and non-attenuation-corrected DH-PET was almost similar for lesions >20 mm, whereas attenuation correction increased the detection rate from 60% to 80% for lesions ≤20 mm (P<0.01). A patient-based analysis revealed concordant results relative to attenuation-corrected ring PET for non-attenuation-corrected ring PET, attenuation-corrected DH-PET and non-attenuation-corrected DH-PET in 42 (93%), 36 (80%) and 31 (69%) patients, respectively. Differences might have influenced patient management in two (4%), six (13%) and ten (22%) patients, respectively. In conclusion, measured attenuation correction markedly improves the lesion detection capability of DH-PET. With measured attenuation correction the diagnostic performance of DH-PET is closer to that of dedicated ring PET.
未经治疗的肺癌：在非衰减校正 2-[氟-18]氟-2-脱氧-D-葡萄糖 PET 扫描中对肿瘤大小和形状的系统失真进行量化。
影响因子：
19.7
作者：
Zasadny,KR;Kison,PV;Quint,LE;Wahl,RL
通讯作者：
Wahl,RL