The risk for psychiatric disorders in relatives of schizophrenic and control probands: A comparison of three independent studies
The risk for psychiatric disorders in relatives of schizophrenic and control probands: A comparison of three independent studies
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DOI：
10.1017/s003329179600445x
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发表时间：
1997-03-01
影响因子：
6.9
通讯作者：
Gardner, CO
中科院分区：
文献类型：
--
作者：
Kendler, KS;Gardner, CO
背景虽然复制是科学的核心，但精神病遗传学家很少有机会复制研究结果，尤其是不止一次。本文回顾了三个独立的精神分裂症家庭研究的结果，其中一个我们进行了诊断审查：丹麦收养研究（DAS），爱荷华州500非500家庭研究（IFS），和罗斯康门家庭研究（RFS）。我们采用DSM-III或DSM-III-R标准和荟萃分析技术。在精神分裂症、其他非情感性精神病（ONAP）、典型人格障碍（SPD）、单极情感性疾病（UPAI）、双相情感性疾病（BPAI）和焦虑症的个人访谈、一级生物学亲属和匹配对照先证者中，各研究的优势比（OR）均相同。对于酗酒，OR显著异质。精神分裂症，SPD和ONAP强烈聚集在精神分裂症先证者的亲属中，共同OR分别为16.2，5.0和4.0。焦虑症的共同OR为1.1，表明无家族聚集性。对于UPAI和BPAI，共同OR超过1（分别为1.3和1.9），尽管只有前者具有统计学意义。精神分裂症在家庭中有很强的聚集性，与SPD和ONAP有家族因素，但与焦虑症没有。精神分裂症和情感性疾病的家族因素或病因学重要性可能是弱相关的。除了酒精中毒，精神分裂症患者和对照组先证者亲属的精神障碍模式在这三项研究中是足够相似的，尽管他们的方法不同，他们可能被视为彼此的复制。
Background. Although replication is the heart of science, psychiatric geneticists rarely have the opportunity to replicate findings, especially more than once.Methods. This article reviews results from three independent family studies of schizophrenia on which one of us conducted diagnostic reviews: the Danish Adoption Study (DAS), the Iowa 500 non-500 family study (IFS), and the Roscommon Family Study (RFS). We utilized DSM-III or DSM-III-R criteria and meta-analysis techniques.Results. The odds ratios (OR) in personally interviewed, first degree biological relatives of schizophrenic and matched control probands for schizophrenia, other non-affective psychoses (ONAP), schizotypal personality disorder (SPD), unipolar affective illness (UPAI), bipolar affective illness (BPAI), and anxiety disorders were homogeneous across studies. For alcoholism, ORs were significantly heterogeneous. Schizophrenia, SPD and ONAP strongly aggregated in relatives of schizophrenic probands with decreasing common OR estimates of 16.2, 5.0 and 4.0, respectively. The common OR for anxiety disorders was 1.1, indicating no familial coaggregation. For UPAI and BPAI, the common ORs exceeded unity (1.3 and 1.9, respectively), although only the former was statistically significant.Conclusions. Schizophrenia strongly aggregates in families and shares familial factors with SPD and ONAP but not anxiety disorders. The familial factors or aetiological importance for schizophrenia and affective illness may be weakly related. With the exception of alcoholism, the patterns of psychiatric disorders in relatives of schizophrenic and control probands in these three studies were sufficiently similar that, despite their methodological differences, they can probably be viewed as replications of one another.