Antimicrobial and Healing Efficacy of Sustained Release Nitric Oxide Nanoparticles Against Staphylococcus Aureus Skin Infection
Antimicrobial and Healing Efficacy of Sustained Release Nitric Oxide Nanoparticles Against Staphylococcus Aureus Skin Infection
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DOI：
10.1038/jid.2009.95
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发表时间：
2009-10-01
影响因子：
6.5
通讯作者：
Friedman, Joel M.
中科院分区：
文献类型：
--
作者：
Martinez, Luis R.;Han, George;Friedman, Joel M.
金黄色葡萄球菌（SA）是社区和医院环境中浅表感染和侵袭性感染的主要原因，经常导致慢性难治性疾病。必须开发出细菌不太可能产生耐药性的创新疗法，以减少相关的发病率和死亡率，并最终提高我们治疗这些感染的能力。在这项研究中，一种以前未报道的一氧化氮（NO）释放纳米颗粒技术被应用于治疗耐甲氧西林SA （MRSA）伤口感染。结果表明，纳米颗粒在小鼠伤口模型中对MRSA具有抗菌活性。与对照组相比，一氧化氮治疗组的感染伤口愈合速度加快。伤口的组织学显示，纳米NO治疗减少了化脓性炎症，减少了细菌负担，减少了胶原降解，为生物活性提供了潜在的机制。总之，这些数据表明，这些释放no的纳米颗粒有潜力作为一种新型的局部应用抗菌剂，用于治疗皮肤感染和伤口。
Staphylococcus aureus (SA) is a leading cause of both superficial and invasive infections in community and hospital settings, frequently resulting in chronic refractory disease. It is imperative that innovative therapeutics to which the bacteria are unlikely to evolve resistance be developed to curtail associated morbidity and mortality and ultimately improve our capacity to treat these infections. In this study, a previously unreported nitric oxide (NO)-releasing nanoparticle technology is applied to the treatment of methicillin-resistant SA (MRSA) wound infections. The results show that the nanoparticles exert antimicrobial activity against MRSA in a murine wound model. Acceleration of infected wound closure in NO-treated groups was clinically shown compared with controls. The histology of wounds revealed that NO nanoparticle treatment decreased suppurative inflammation, minimal bacterial burden, and less collagen degradation, providing potential mechanisms for biological activity. Together, these data suggest that these NO-releasing nanoparticles have the potential to serve as a novel class of topically applied antimicrobials for the treatment of cutaneous infections and wounds.