Transcriptional Regulation and Implications for Controlling Hox Gene Expression.
Transcriptional Regulation and Implications for Controlling Hox Gene Expression.
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DOI：
10.3390/jdb10010004
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发表时间：
2022-01-10
影响因子：
2.7
通讯作者：
Krumlauf R
中科院分区：
文献类型：
--
作者：
Afzal Z;Krumlauf R
在从无脊椎动物到脊椎动物的各种动物中，Hox基因在轴向模式和调节细胞和组织的区域特性中起着关键作用。Hox表达的嵌套结构域生成一个组合代码，该代码提供了一个分子框架，用于指定沿a - p轴的组织特性。因此，了解协调控制聚集性Hox基因在发育中的作用所需的精确转录模式的调节机制是很重要的。关于转录调控的动力学和分子机制的新见解正在出现，并且有兴趣了解这些如何在促进簇状Hox基因表达的调控中发挥作用。在这篇综述中，我们总结了一些最近的发现、观点和新兴的机制，这些机制是转录调控的基础，并考虑它们如何与理解Hox基因的转录调控相关。
Hox genes play key roles in axial patterning and regulating the regional identity of cells and tissues in a wide variety of animals from invertebrates to vertebrates. Nested domains of Hox expression generate a combinatorial code that provides a molecular framework for specifying the properties of tissues along the A–P axis. Hence, it is important to understand the regulatory mechanisms that coordinately control the precise patterns of the transcription of clustered Hox genes required for their roles in development. New insights are emerging about the dynamics and molecular mechanisms governing transcriptional regulation, and there is interest in understanding how these may play a role in contributing to the regulation of the expression of the clustered Hox genes. In this review, we summarize some of the recent findings, ideas and emerging mechanisms underlying the regulation of transcription in general and consider how they may be relevant to understanding the transcriptional regulation of Hox genes.