The Palau Early Psychosis Study: distribution of cases by level of genetic risk.
The Palau Early Psychosis Study: distribution of cases by level of genetic risk.
复制标题
帕劳早期精神病研究：按遗传风险水平划分的病例分布。
DOI：
10.1002/ajmg.b.30362
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Faraone,StephenV
中科院分区：
文献类型：
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作者：
Myles-Worsley,Marina;Blailes,Francisca;Ord,LisaM;Weaver,Starla;Dever,Gregory;Faraone,StephenV
帕劳早期精神病研究(PEPS)旨在研究高危人群隔离中早期精神病的发病机制。本文描述了我们以社区为基础的、404名帕劳青少年的非求助样本的特征，并根据遗传风险水平量化了早期精神病的存在。样本包括一位精神分裂症父母的53个子女(GHR+)和68个兄弟姐妹/三人组(GHR+)的侄女/侄子，被指定为“遗传高危”(GHR)。其余的受试者是通过一项高中调查招募的，该调查确定了62名有受影响的二级或三级亲属的“遗传中等风险”(GMR)青少年和221名没有近亲的“遗传低风险”(GLR)受试者。GLR青少年包括117名有症状或“临床高危”青少年和104名无症状的正常对照。基于改良的K-SADS-PL评估，我们确定了221名患有早期精神病的青少年，其中62人或28%已经过渡到精神障碍。这两个最高风险群体加在一起，贡献了31%的青少年首发精神病病例和27%的前驱症状。超过一半的早期精神病病例(53%)是GLR青少年。DSM-IV精神病的平均发病年龄为12.9岁，男性的过渡年龄早于女性。我们的结果表明，帕劳青少年，甚至没有近亲的GLR青少年，早期精神病的发生率都很高。这些年轻的受试者可以提供关于精神分裂症的家族传播、疾病的发展过程以及转变为坦率精神病的比率的有价值的信息。©2006 Wiley-Liss，Inc.
The Palau Early Psychosis Study (PEPS) was designed to examine the pathogenesis of early psychosis in a high‐risk population isolate. This paper describes the characteristics of our community‐based, non‐help seeking sample of 404 Palauan adolescents and quantifies the presence of early psychosis by level of genetic risk. The sample included 53 offspring of a schizophrenic parent designated as “Genetically Highest Risk” (GHR+) and 68 nieces/nephews of sib‐pairs/trios, designated as “Genetically High Risk” (GHR). The remaining subjects were recruited through a high school survey that identified 62 “Genetically Moderate Risk” (GMR) adolescents with an affected second or third degree relative and 221 “Genetically Low Risk” (GLR) subjects with no close affected relatives. The GLR adolescents included 117 symptomatic or “Clinically High Risk” (CHR) adolescents and 104 asymptomatic normal controls. Based on a modified K‐SADS‐PL assessment, we identified 221 adolescents with early psychosis, 62 or 28% of whom had already transitioned to a psychotic disorder. Together, the two highest risk groups contributed 31% of the adolescent‐onset psychosis cases and 27% of the prodromals. More than half of the early psychosis cases (53%) were GLR adolescents. The mean age of onset for DSM‐IV psychosis was 12.9 years, and males transitioned at an earlier age than females. Our results indicate that Palauan adolescents, even GLR adolescents with no close affected relatives, have elevated rates of early psychosis. These young subjects can contribute valuable information about the familial transmission of schizophrenia, the developmental course of the illness, and rates of transition to frank psychosis. © 2006 Wiley‐Liss, Inc.