Amino Acid Transporters and Glutamine Metabolism in Breast Cancer.
Amino Acid Transporters and Glutamine Metabolism in Breast Cancer.
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DOI：
10.3390/ijms19030907
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发表时间：
2018-03-19
影响因子：
5.6
通讯作者：
Koo JS
中科院分区：
文献类型：
--
作者：
Cha YJ;Kim ES;Koo JS
氨基酸转运蛋白是膜转运蛋白，其中大多数是溶质载体家族的成员。氨基酸对于包括肿瘤细胞在内的所有类型细胞的生存至关重要，肿瘤细胞对营养物质的需求增加，以促进增殖和癌症进展。乳腺癌是全世界女性最常见的恶性肿瘤，尽管治疗策略有所改善，但仍然与高死亡率相关。最近的研究表明，乳腺癌中氨基酸代谢途径发生改变，氨基酸转运蛋白影响肿瘤的生长和进展。在乳腺癌中，谷氨酰胺是关键营养素之一，谷氨酰胺代谢与氨基酸转运蛋白密切相关。在这篇综述中，我们重点关注氨基酸转运蛋白及其在乳腺癌中的作用。我们还重点介绍了乳腺癌中上调氨基酸转运蛋白的不同子集，并讨论了它们作为治疗靶点、癌症成像示踪剂和药物输送成分的潜在应用。还讨论了谷氨酰胺代谢及其在乳腺癌中的调节和治疗意义。
Amino acid transporters are membrane transport proteins, most of which are members of the solute carrier families. Amino acids are essential for the survival of all types of cells, including tumor cells, which have an increased demand for nutrients to facilitate proliferation and cancer progression. Breast cancer is the most common malignancy in women worldwide and is still associated with high mortality rates, despite improved treatment strategies. Recent studies have demonstrated that the amino acid metabolic pathway is altered in breast cancer and that amino acid transporters affect tumor growth and progression. In breast cancer, glutamine is one of the key nutrients, and glutamine metabolism is closely related to the amino acid transporters. In this review, we focus on amino acid transporters and their roles in breast cancer. We also highlight the different subsets of upregulated amino acid transporters in breast cancer and discuss their potential applications as treatment targets, cancer imaging tracers, and drug delivery components. Glutamine metabolism as well as its regulation and therapeutic implication in breast cancer are also discussed.
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影响因子：
45.3
作者：
Bartlett, John M. S.;Bloom, Kenneth J.;Rea, Daniel
通讯作者：
Rea, Daniel
MYC调节谷氨酰胺 - 丙啉调节轴是腔内B乳腺癌的关键。
影响因子：
8.8
作者：
Craze ML;Cheung H;Jewa N;Coimbra NDM;Soria D;El-Ansari R;Aleskandarany MA;Wai Cheng K;Diez-Rodriguez M;Nolan CC;Ellis IO;Rakha EA;Green AR
通讯作者：
Green AR
影响因子：
4.4
作者：
Budczies J;Denkert C;Müller BM;Brockmöller SF;Klauschen F;Györffy B;Dietel M;Richter-Ehrenstein C;Marten U;Salek RM;Griffin JL;Hilvo M;Orešič M;Wohlgemuth G;Fiehn O
通讯作者：
Fiehn O
影响因子：
11.5
作者：
Baek, Sora;Choi, Chang-Min;Moon, Dae Hyuk
通讯作者：
Moon, Dae Hyuk
影响因子：
7.4
作者：
Bartlett, John M. S.;Thomas, Jeremy;Chetty, Udi
通讯作者：
Chetty, Udi