Cord Blood 25-Hydroxyvitamin D Levels and the Risk of Acute Lower Respiratory Tract Infection in Early Childhood
Cord Blood 25-Hydroxyvitamin D Levels and the Risk of Acute Lower Respiratory Tract Infection in Early Childhood
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DOI：
10.1093/tropej/fms042
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发表时间：
2013-02-01
影响因子：
2
通讯作者：
Al-Shehri, M. A.
中科院分区：
文献类型：
--
作者：
Mohamed, W. A. Wahab;Al-Shehri, M. A.
目的：确定脐带血 25-羟基维生素 D [25 (OH) D] 浓度与出生后 2 年内发生急性下呼吸道感染 (ALRI) 的风险之间的关系。患者和方法：对 206 名新生儿的脐带血进行 25 (OH) D 检测。回顾了出生前 2 年的医疗记录，并记录了 ALRI 的诊断。结果： 62 名 (30.1%) 婴儿在出生后 2 年内患上 ALRI，其中 49 名 (79%) 婴儿患有细支气管炎，13 名 (21%) 婴儿患有肺炎。与未患 ALRI 的婴儿相比，患 ALRI 的婴儿 25 (OH) D 浓度较低 (p < 0.0001)。维生素 D 缺乏与 ALRI 风险增加相关 (p = 0.000)。结论：脐带血 25 (OH) D 水平低与出生后 2 年内 ALRI 风险增加相关。
Objective: To determine the relationship between cord blood 25-hydroxyvitamin D [25 (OH) D] concentrations and the subsequent risk of acute lower respiratory tract infection (ALRI) in the first 2 years of life.Patients and Methods: Cord blood from 206 newborns was tested for 25 (OH) D. Medical records covering the first 2 years of life were reviewed, and the diagnosis of ALRI was recorded.Results: Sixty-two (30.1%) infants developed ALRI in their first 2 years of life, of whom 49 (79%) infants had bronchiolitis and 13 (21%) infants had pneumonia. Concentrations of 25 (OH) D were lower in infants who developed ALRI compared with those did not (p < 0.0001). Vitamin D deficiency was associated with increased risk of ALRI (p = 0.000).Conclusion: Low cord blood 25 (OH) D levels are associated with increased risk of ALRI in the first 2 years of life.