Altered white matter microstructural integrity revealed by voxel-wise analysis of diffusion tensor imaging in welders with manganese exposure
Altered white matter microstructural integrity revealed by voxel-wise analysis of diffusion tensor imaging in welders with manganese exposure
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DOI：
10.1016/j.neuro.2010.11.004
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发表时间：
2011-01-01
期刊：
影响因子：
3.4
通讯作者：
Chang, Yongmin
中科院分区：
文献类型：
--
作者：
Kim, Yangho;Jeong, Kyoung Sook;Chang, Yongmin
长期暴露于锰（Mn）可造成职业危害或肝功能衰竭，与不良的运动和认知结果相关。先前神经影像学和磁共振波谱学研究的证据表明，mn暴露的大脑功能发生改变。然而，长期暴露于Mn对人脑白质（WM）结构的影响尚未确定。在本研究中，我们使用扩散张量成像（DTI）来调查暴露于Mn的焊工与对照组相比，WM完整性是否存在差异。在体素基础上测量了30名接触锰的男性焊工和19名年龄和性别匹配的对照组的分数各向异性（FA）、平均扩散率（MD）、轴向扩散率（AD）和径向扩散率（RD）。使用独立于研究者的统计参数映射（SPM）对DTI指标进行体素分析，焊工和对照组之间的直接比较显示，mn暴露焊工的胼胝体（CC） FA和额部WM减少。此外，RD的显著增加和AD的可忽略的变化表明，CC和额部WM的微结构变化是由于这些区域的纤维径向性受损，主要是由脱髓鞘引起的。与神经行为表现的相关分析也表明，微观结构异常与焊工细微的运动和认知差异有关。(C) 2010爱思唯尔公司版权所有。
Chronic exposure to manganese (Mn), which can be an occupational hazard or can result from liver failure, is associated with adverse motor and cognitive outcomes. Evidence from previous neuroimaging and magnetic resonance spectroscopy studies suggested alteration of function in Mn-exposed brains. However, the effect of chronic exposure of the human brain to Mn on white matter (WM) structure has not yet been determined. In the present study, we used diffusion tensor imaging (DTI) to investigate whether welders exposed to Mn demonstrate differences in WM integrity, compared with control subjects. Fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were measured on a voxel-wise basis in 30 male welders with exposure to Mn and in 19 age- and gender-matched control subjects. Direct comparison between welders and controls using investigator-independent Statistical Parametric Mapping (SPM) voxel-wise analysis of DTI metrics revealed a reduction of FA in the corpus callosum (CC) and frontal WM in Mn-exposed welders. Further, marked increases in RD and negligible changes in AD suggested that the microstructural changes in the CC and frontal WM result from compromised radial directionality of fibers in these areas, caused primarily by demyelination. Correlation analysis with neurobehavioral performance also suggested that the microstructural abnormalities were associated with subtle motor and cognitive differences in welders. (C) 2010 Elsevier Inc. All rights reserved.