Conservation surgery and radiation therapy in early breast cancer - An update.
Conservation surgery and radiation therapy in early breast cancer - An update.
复制标题
早期乳腺癌的保留手术和放射治疗 - 更新。
DOI：
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复制
发表时间：
2017
影响因子：
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通讯作者：
John Boyages Am
中科院分区：
文献类型：
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作者：
Ellen Tailby;John Boyages Am
背景
多项随机试验和荟萃分析支持使用保守手术（CS）和放射治疗（RT）治疗早期乳腺癌。肿瘤切除术后，与单纯肿瘤切除术相比，RT已被证明可降低局部复发的机会并提高总生存率。
目的
本更新概述了CS和RT的原理和结局，是否存在可以安全省略RT的亚组，RT的过程，常见副作用及其管理，以及该领域的最新技术。
讨论
保留乳房仍然是乳腺癌的有效治疗方法，与乳房切除术相比没有生存劣势。先进的成像和快速三维（3D）放射治疗计划计算机系统的结合，使新技术能够更准确地提供RT，更好地控制肿瘤，减少副作用并提高生存率。
BACKGROUND
Multiple randomised trials and meta-analyses have supported the use of conservative surgery (CS) and radiation therapy (RT) for the treatment of early-stage breast cancer. Following lumpectomy, RT has been shown to decrease the chance of local recurrence and improve overall survival when compared with lumpectomy alone.
OBJECTIVE
This update outlines the rationale and outcomes for CS and RT, whether a subgroup exists in which RT may be safely omitted, the process of RT, common side effects and their management, and the latest techniques in the field.
DISCUSSION
Breast conservation remains an effective treatment for breast cancer without a survival disadvantage to a mastectomy. The combination of advanced imaging and fast three-dimensional (3D) radiotherapy planning computer systems have allowed new techniques that deliver RT more accurately, with better tumour control, fewer side effects and improved survival.