The chronic bronchitis phenotype in chronic obstructive pulmonary disease: features and implications.
The chronic bronchitis phenotype in chronic obstructive pulmonary disease: features and implications.
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DOI：
10.1097/mcp.0000000000000145
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发表时间：
2015-03
影响因子：
3.3
通讯作者：
Criner GJ
中科院分区：
文献类型：
--
作者：
Kim V;Criner GJ
慢性阻塞性肺疾病(COPD)是一个重大的公共卫生问题，预计在疾病负担方面将在全球排名第五，在死亡率方面将排名第三。慢性支气管炎(CB)与多种临床后果相关，包括加速肺功能下降，增加病情恶化的风险，降低与健康相关的生活质量，并可能增加全因死亡率。最近的数据表明，对危险因素、放射学特征和治疗方案有更多的解释。我们的目标是回顾过去几年发表的有关慢性支气管炎的文献。越来越多的文献更详细地描述了与慢性病相关的环境风险因素、流行病学和遗传学。此外，随着计算机断层扫描技术的不断改进，与CB相关的放射表型也得到了更好的理解。有了这些新的数据，临床医生可以识别新描述的慢性支气管炎的危险因素和相关的表型，并为这一高危人群提供新的治疗选择。
Chronic Obstructive Pulmonary Disease (COPD) is a major public health problem that is projected to rank fifth worldwide in terms of disease burden and third in terms of mortality. Chronic bronchitis (CB) is associated with multiple clinical consequences, including hastening lung function decline, increasing risk of exacerbations, reducing health related quality of life, and possibly raising all-cause mortality. Recent data suggests greater elucidation on the risk factors, radiologic characteristics, and treatment regimens. Our goal was to review the literature on chronic bronchitis that has been published in the last few years. A growing body of literature that more carefully describes environmental risk factors, epidemiology, and genetics associated with CB. In addition, as computed tomography technology continues to improve, the radiologic phenotype associated with CB is better understood. With these new data, the clinician can recognize the newly described risk factors and the associated phenotype for chronic bronchitis and entertain new treatment options for this high risk population.