Role of Hematopoietic Cells in the Maintenance of Chronic Human Torquetenovirus Plasma Viremia
Role of Hematopoietic Cells in the Maintenance of Chronic Human Torquetenovirus Plasma Viremia
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DOI：
10.1128/jvi.00273-10
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发表时间：
2010-07-01
影响因子：
5.4
通讯作者：
Bendinelli, Mauro
中科院分区：
文献类型：
--
作者：
Maggi, Fabrizio;Focosi, Daniele;Bendinelli, Mauro
扭矩病毒（TTV）生命周期的许多方面基本上尚未被探索。特别是，哪种细胞类型复制病毒并维持受感染宿主血液中普遍较高的病毒载量仍然是一个猜测。在这项研究中，我们连续测量了四名 TTV 阳性白血病患者血浆中的 TTV 负荷，这些患者接受了强烈的骨髓抑制，然后移植了半相合造血干细胞。这些发现为造血细胞在 TTV 病毒血症的维持中发挥极其重要的作用提供了明确的定量证据。
Many aspects of the life cycle of torquetenoviruses (TTVs) are essentially unexplored. In particular, it is still a matter of speculation which cell type(s) replicates the viruses and maintains the generally high viral loads found in the blood of infected hosts. In this study, we sequentially measured the TTV loads in the plasma of four TTV-positive leukemia patients who were strongly myelosuppressed and then transplanted with haploidentical hematopoietic stem cells. The findings provide clear quantitative evidence for an extremely important role of hematopoietic cells in the maintenance of TTV viremia.