PROSENCEPHALIC MECHANISMS OF ECOG DESYNCHRONIZATION IN CERVEAU-ISOLE CATS
PROSENCEPHALIC MECHANISMS OF ECOG DESYNCHRONIZATION IN CERVEAU-ISOLE CATS
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DOI：
10.1016/0013-4694(77)90028-1
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发表时间：
1977-01-01
期刊：
影响因子：
--
通讯作者：
MANCIA, M
中科院分区：
文献类型：
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作者：
BELARDETTI, F;BORGIA, R;MANCIA, M
在急性和慢性的头侧鹿岛猫（额状面 3 或 4 的切片）中，对基底前脑区域的高频刺激会引起强直 ECoG [皮质电图] 去同步化，伴随着纺锤体的突然取消，这种情况总是比刺激期持续得更久。对视前区的探索表明，刺激紧邻交叉上方的区域后效果最大。下丘脑后部的高频刺激引起的 ECoG 激活在所有方面都与急性和慢性制剂中基底前脑刺激后相似。最有效的区域位于腹内侧。与新皮质去同步化平行，θ。视前区和下丘脑的激活在背侧海马中诱发波。这种效应在间隔核急性凝固后消失。在急性鹿岛制剂中，对腹侧杏仁核的高频刺激导致背景同步没有显着变化。刺激背侧杏仁核诱导阶段性 ECoG 激活，但该激活不会持续超过刺激期。有时，在刺激背核后，可以看到仅限于同侧半球的强直皮质唤醒。在任何情况下，嗅觉刺激都不会改变 ECoG 同步。在高频刺激层内丘脑核期间也发现皮质激活的缺失。注射巴比妥酸盐（2-20 mg/kg，静脉注射）增加了自发同步，同时逐渐缩短并最终消除了由基底前脑和下丘脑后部刺激引起的皮层电激活。在头侧水平横断脑干的准备中，下丘脑前部（视前部）和后部可能对皮质产生强直去同步影响，这不需要脑干网状激活系统的支持。背侧杏仁核对皮质电活动的控制似乎是由脑干介导的。
In acute and chronic rostral cerveau isole cats (section at frontal plane 3 or 4) high-frequency stimulation of basal forebrain regions induced tonic ECoG [electrocorticogram] desynchronization with abrupt abolition of spindles, which always outlasted the period of stimulation. Exploration of the preoptic area showed that the maximal effect followed stimulation of regions immediately above the chiasma. High-frequency stimulation of the posterior hypothalamus induced ECoG activation similar in all respects to that after basal forebrain stimulation in both acute and chronic preparations. The most effective area was situated ventro-medially. Paralled to neocortical desynchronization, .theta. waves were induced in the dorsal hippocampus by both preoptic and hypothalamic activation. This effect disappeared after acute coagulation of septal nuclei. In acute cerveau isole preparations high-frequency stimulation of the ventral amygdala led to no significant change in the background synchronization. Stimulation of the dorsal amygdala induced phasic ECoG activation which did not outlast the stimulation period. Occasionally a tonic cortical arousal limited to the ipsilateral hemisphere could be seen following stimulation of dorsal nuclei. In no case did olfactory stimulation modify the ECoG synchronization. An absence of cortical activation was also found during high-frequency stimulation of intralaminar thalamic nuclei. Injection of barbiturate (from 2-20 mg/kg, i.v.) increased the spontaneous synchronization while it progressively shortened and eventually abolished the electrocortical activation induced by stimulation of the basal forebrain and the posterior hypothalamus. In preparations with transection of the brain-stem at a rostral level both the anterior (preoptic) and posterior hypothalamus may have a tonic desynchronizing influence on the cortex, which requires no support from the reticular activating system of the brain-stem. The control exerted by dorsal amygdala on the electrical activity of the cortex appeared instead to be mediated by the brainstem.