Non-food bioactive product (+)-nootkatone: Chemistry and biological activities
Non-food bioactive product (+)-nootkatone: Chemistry and biological activities
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DOI：
10.1016/j.indcrop.2021.114490
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发表时间：
2022-01-03
影响因子：
5.9
通讯作者：
Guo, Yong
中科院分区：
文献类型：
--
作者：
Fan, Jiangping;Liu, Zhiyan;Guo, Yong
（+）-努特卡酮是一种非食用的天然倍半萜酮，首先从阿拉斯加黄杉（Chamaerosparis nootkatensis）的心材中分离得到.由于其强烈的葡萄柚香气和广泛的生物活性，在食品，化妆品，制药和化学工业中对（+）-诺卡酮的需求不断增长。因此，有必要联合收割机结合最新的和以前可获得的信息，了解（+）-诺卡酮的研究现状，为（+）-诺卡酮及其类似物的进一步开发铺平道路。本文综述了（+）-诺卡酮的植物来源、化学合成、生物合成、结构修饰以及（+）-诺卡酮及其衍生物的杀虫和生理活性等方面的研究进展。希望本工作能为进一步开发（+）-诺卡酮及其类似物在食品、化妆品、医药、化工等领域的应用提供参考。
(+)-Nootkatone, first isolated from the heartwood of Alaska yellow cedar (Chamaecyparis nootkatensis), is a non -food natural sesquiterpene ketone. Due to its strong grapefruit aroma and wide range of biological activities, there is a growing demand for (+)-nootkatone in the food, cosmetic, pharmaceutical, and chemical industries. Therefore, there is a need to combine the latest and previously available information to understand the research status of (+)-nootkatone and to pave a way for the further development of (+)-nootkatone and its analogs. The present work reviews the research progress in the plant sources, chemical synthesis, biosynthesis, and structural modifications of (+)-nootkatone, and the pesticidal and other physiological activities of (+)-nootkatone and its derivatives. We hope this work can provide a reference for the further application of (+)-nootkatone and its analogs in the food, cosmetic, pharmaceutical, and chemical industries.