A quantitative comparison of cellular motile systems.
A quantitative comparison of cellular motile systems.
复制标题
细胞运动系统的定量比较。
DOI：
10.1002/cm.970040102
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Nicklas,RB
中科院分区：
文献类型：
--
作者：
Nicklas,RB
不同的细胞运动系统，如肌肉和有丝分裂纺锤体，已经通过它们的特定功率输出进行了比较：它们每单位发动机体积产生的最大功率。横纹肌和鞭毛具有高的比输出；其性能可与典型的汽车发动机相媲美。细胞动力学沟和有丝分裂纺锤体的比功率输出要低得多。犁沟的产出比肌肉低7000倍，而纺锤的产出比肌肉低30万倍。不同的大分子在输出相似的系统（肌肉和鞭毛）中被用来产生能量，相反，相同的大分子马达在输出非常不同的系统（肌肉和细胞动力学沟）中被使用。这种多样性的共同特征是对特定生物作用的适应，具体的功率输出很好地反映了这一点。大功率、紧凑型发动机应该发挥优势的地方值高，而精度而不是功率最重要的地方值低。
Cellular motile systems as diverse as muscle and the mitotic spindle have been compared by their specific power output: the maximum power they develop per unit of engine volume. Striated muscles and flagella have high specific output; their performance is comparable to that of typical automobile engines. The cytokinetic furrow and the mitotic spindle have very much lower specific power output. The furrow's output is 7,000 times lower than muscle and the spindle's is 300,000 times lower. Different macromolecules have been used to generate power in systems with similar output (muscles and flagella) and, conversely, the same macromolecular motor has been used in systems with very different output (muscles and cytokinetic furrows). The common feature amid this diversity is adaptation to a particular biological role, which specific power output reflects very well. High values are found where a powerful, compact engine should be advantageous, while low values are found where precision, not power, matters most.