Cognitive rigidity in unipolar depression and obsessive compulsive disorder: Examination of task switching, Stroop, working memory updating and post-conflict adaptation
Cognitive rigidity in unipolar depression and obsessive compulsive disorder: Examination of task switching, Stroop, working memory updating and post-conflict adaptation
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DOI：
10.1016/j.psychres.2010.04.044
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发表时间：
2011-01-30
影响因子：
11.3
通讯作者：
Nemets, Boris
中科院分区：
文献类型：
--
作者：
Meiran, Nachshon;Diamond, Gary M.;Nemets, Boris
强迫症（OCD）和抑郁性沉思都以认知僵化为特征。我们检查了 17 名患者（9 名患有单相抑郁症 [UD] 但不伴有强迫症，8 名患有强迫症但不伴有 UD）和 17 名年龄、性别、语言和教育程度相匹配的对照参与者在涵盖四种主要执行功能的电池上的表现。结果表明，在这两种疾病中，患者在经历任务切换后需要更多的试验来适应单任务条件，反映出从切换模式中缓慢脱离，并且与对照组相比，在高冲突斯特鲁普试验后表现出异常的冲突后处理模式适应。反刍思维在 UD 中升高，而在强迫症中则没有，与工作记忆更新不良和任务准备较少有关。结果表明，在目前测试的范式中，OCD 和 UD 与类似的认知僵化相关。 (C) 2010 Elsevier Ireland Ltd. 保留所有权利。
Obsessive compulsive disorder (OCD) and depressive rumination are both characterized by cognitive rigidity. We examined the performance of 17 patients (9 suffering from unipolar depression [UD] without OCD, and 8 suffering from OCD without UD), and 17 control participants matched on age, gender, language and education, on a battery covering the four main executive functions. Results indicated that, across both disorders, patients required more trials to adjust to single-task conditions after experiencing task switching, reflecting slow disengagement from switching mode, and showed abnormal post-conflict adaptation of processing mode following high conflict Stroop trials in comparison to controls. Rumination, which was elevated in UD and not in OCD, was associated with poor working memory updating and less task preparation. The results show that OCD and UD are associated with similar cognitive rigidity in the presently tested paradigms. (C) 2010 Elsevier Ireland Ltd. All rights reserved.