The bidirectional effects of shock on alcohol preference in rats.
The bidirectional effects of shock on alcohol preference in rats.
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休克对大鼠酒精偏好的双向影响。
DOI：
10.1111/j.1530-0277.1990.tb01837.x
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Hopson,N
中科院分区：
文献类型：
--
作者：
Volpicelli,JR;Ulm,RR;Hopson,N
与未受电击的动物相比，让老鼠在5%的酒精溶液和水之间进行选择的老鼠，在经历不可避免的电击后的几天里，会显著增加对酒精的偏好。虽然在休克日中，总体酒精偏好没有差异，但休克应激和酒精偏好之间存在交互作用。最初偏爱酒精的大鼠在休克日降低了酒精偏好，而最初避免酒精的大鼠在休克日增加了酒精偏好。因此，不可避免的电击应激对酒精偏好有双向影响。这些双向效应取决于酒精消费与休克体验和最初的酒精偏好相关的时间动态。
Rats given a choice between a 5% alcohol solution and water will dramatically increase alcohol preference on the days following experience with inescapable electric footshocks, compared with unshocked animals. Although, total alcohol preference did not differ during shock days, an interaction occurred between shock stress and alcohol preference. Rats that initially preferred alcohol decreased alcohol preference during shock days, whereas, rats that initially avoided alcohol increased alcohol preference during shock days. Therefore, the stress of inescapable electric footshock has bidirectional effects on alcohol preference. These bidirectional effects depend on the temporal dynamics of alcohol consumption in relation to the shock experience and the initial alcohol preference.