Effects of cocaine combined with a social cue on conditioned place preference and nucleus accumbens monoamines after isolation rearing in rats.
Effects of cocaine combined with a social cue on conditioned place preference and nucleus accumbens monoamines after isolation rearing in rats.
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DOI：
10.1007/s00213-014-3470-0
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发表时间：
2014-08
影响因子：
3.4
通讯作者：
Bland ST
中科院分区：
文献类型：
--
作者：
Grotewold SK;Wall VL;Goodell DJ;Hayter C;Bland ST
吸毒期间的社会互动可以增强可卡因奖励。青少年时期的孤立抚养（ISO）增加了社会互动，并可能放大这种增强作用。本研究的目的是确定当与社会线索结合时，ISO是否会改变可卡因的条件位置偏好（CPP），以及当与社会线索结合时，ISO是否会改变可卡因对伏隔核壳（NAcS）多巴胺（DA）和血清素（5-HT）的影响。雄性和雌性大鼠分别在青春期饲养4周。CPP使用低剂量的可卡因（2mg /kg或生理盐水）进行，在条件反射期间或不暴露于新的同性同性。使用相同的参数进行体内微透析。相对于GRP， ISO大鼠在条件反射过程中表现出更多的社交和攻击行为。可卡因减少了所有老鼠的社交和攻击行为。CPP不受饲养条件的影响。可卡因产生显著的CPP，而社会线索只在男性中产生CPP。相比之下，可卡因和社会线索对NAcS DA和5-HT的相互作用因饲养条件的不同而不同。在分离株中，可卡因诱导的DA被减弱，而可卡因加上社会线索则产生增强的DA和5-HT。在存在社会提示的情况下暴露于低剂量可卡因对ISO大鼠NAcS的CPP产生加性效应，同时对DA和5-HT产生协同效应。这种复合刺激的厌恶效应可能会抵消分离物的奖励效应。
Social interaction during drug exposure can potentiate cocaine reward. Isolation rearing (ISO) during adolescence increases social interaction and may amplify this potentiation. The objectives of this study are to determine whether ISO alters conditioned place preference (CPP) for cocaine when combined with a social cue and to determine whether ISO alters the effects of cocaine when combined with social cue on nucleus accumbens shell (NAcS) dopamine (DA) and serotonin (5-HT). Male and female rats were either ISO or group (GRP) reared for 4 weeks during adolescence. CPP was performed using a low dose of cocaine (2 mg/kg or saline) with or without exposure to a novel same-sex conspecific during conditioning. In vivo microdialysis was performed using the same parameters. ISO rats engaged in more social and aggressive behaviors during conditioning relative to GRP. Cocaine reduced social and aggressive behaviors in all rats. CPP was not influenced by rearing condition. Cocaine produced significant CPP, and a social cue produced CPP only in males. In contrast, the interaction of cocaine and a social cue on NAcS DA and 5-HT differed depending upon rearing condition. In isolates, cocaine-induced DA was attenuated, while cocaine plus a social cue produced potentiated DA and 5-HT. Exposure to a low dose of cocaine in the presence of a social cue produced additive effects on CPP while producing synergistic effects on DA and 5-HT in the NAcS of ISO rats. The aversive effects of this compound stimulus may negate the rewarding effects in isolates.