Incidence of Postoperative Pneumonia and Oral Microbiome for Patients with Cancer Operation
Incidence of Postoperative Pneumonia and Oral Microbiome for Patients with Cancer Operation
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DOI：
10.3390/app12062920
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发表时间：
2022-03
期刊：
影响因子：
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通讯作者：
Y. Nomura;Yuko Inai;Yudai Shimpo;Ayako Okada;Yuko Yamamoto;Kaoru Sogabe;Naohisa Wada;N. Hanada
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文献类型：
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作者：
Y. Nomura;Yuko Inai;Yudai Shimpo;Ayako Okada;Yuko Yamamoto;Kaoru Sogabe;Naohisa Wada;N. Hanada
术后肺炎对于患者和医务人员来说是一个严重的问题。在日本，许多医院引入围手术期口腔护理管理，以有效利用医疗资源。然而，术后肺炎的发生率仍然很高。因此，需要确定特定的呼吸道病原体来预测肺炎的发病率。本研究的目的是找出术后肺炎的候选细菌种类。本研究对接受或不伴术后肺炎的癌症手术患者采用病例对照研究设计。共有 10 名在全身麻醉下接受癌症手术的患者参与了这项研究。癌症手术前一天，应用术前口腔护理管理。使用下一代序列，在这些患者第一次就诊时、癌症手术前一天和手术后一天对口腔微生物组进行了分析。牙龈卟啉单胞菌和具核梭杆菌群在首次就诊时可能是高风险。癌症手术前的小阿托波菌和粪肠球菌可能具有高风险。口腔卫生不良会增加术后肺炎发生的风险。牙周病原体增多可能是术后肺炎发生的高风险。此外，口腔护理管理后肠道细菌增加也可能是术后肺炎发生的高风险。
Postoperative pneumonia is a serious problem for patients and medical staff. In Japan, many hospitals introduced perioperative oral care management for the efficient use of medical resources. However, a high percentage of postoperative pneumonia still developed. Therefore, there is a need to identify the specific respiratory pathogens to predict the incidence of pneumonia The purpose of this study was to find out the candidate of bacterial species for the postoperative pneumonia. This study applied case-control study design for the patients who had a cancer operation with or without postoperative pneumonia. A total of 10 patients undergoing a cancer operation under general anesthesia participated in this study. The day before a cancer operation, preoperative oral care management was applied. Using the next generation sequence, oral microbiome of these patients was analyzed at the time of their first visit, the day before and after a cancer operation. Porphyromonas gingivalis and Fusobacterium nucleatum group can be a high risk at first visit. Atopobium parvulum and Enterococcus faecalis before a cancer operation can be a high risk. Poor oral hygiene increased the risk of incidence of postoperative pneumonia. Increased periodontal pathogens can be a high risk of the incidence of postoperative pneumonia. In addition, increased intestinal bacteria after oral care management can also be a high risk for the incidence of postoperative pneumonia.