Meta-Analysis of the Efficacy and Safety of Lactobacillus-containing and Bifidobacterium-containing Probiotic Compound Preparation in Helicobacter pylori Eradication Therapy
Meta-Analysis of the Efficacy and Safety of Lactobacillus-containing and Bifidobacterium-containing Probiotic Compound Preparation in Helicobacter pylori Eradication Therapy
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DOI：
10.1097/mcg.0b013e318266f6cf
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发表时间：
2013-01-01
影响因子：
2.9
通讯作者：
Fang, Jing-Yuan
中科院分区：
文献类型：
--
作者：
Wang, Zhen-Hua;Gao, Qin-Yan;Fang, Jing-Yuan
目标：荟萃分析含乳酸杆菌和双歧杆菌的益生菌复合制剂是否能改善幽门螺杆菌（H。pylori）根除率并减少副作用。背景：已有多项研究表明乳杆菌和双歧杆菌对H.幽门。益生菌在临床上的应用更多的是以含乳杆菌和双歧杆菌的益生菌复合制剂的形式出现。研究：我们纳入了所有平行对照试验，比较了在H. pylori根除治疗的Meta分析。使用Stata 11.0版软件进行统计分析。结果：共纳入10个临床试验。1469例患者（益生菌补充组708例，对照组761例）的根除比值比（OR）可用。通过意向治疗分析和符合方案分析，补充益生菌与不补充益生菌的合并OR分别为2.066 [95%置信区间（CI），1.398-3.055]和2.321（95%CI，1.715-3.142）。通过随机模型计算，益生菌补充组的总副作用发生率的合并OR显著降低（OR=0.305; 95%CI，0.117-0.793），无显著出版偏倚。成人幽门螺杆菌根除治疗可能对根除率和总副作用的发生率有有益的影响。
Goals: To meta-analyze whether Lactobacillus-containing and Bifidobacterium-containing probiotic compound preparation could improve Helicobacter pylori (H. pylori) eradication rates and reduce side effects.Background: There have been several studies demonstrating that Lactobacillus and Bifidobacterium species have an inhibitory effect on H. pylori. The application of probiotics in clinical practice is more often in the form of Lactobacillus-containing and Bifidobacterium-containing probiotic compound preparation.Study: We included all parallel controlled trials comparing Lactobacillus-containing and Bifidobacterium-containing probiotic compound preparation supplementation or not during H. pylori eradication therapy in meta-analysis. Statistical analysis was performed with the Stata version 11.0 software. Subgroup analysis and sensitivity analysis were also performed.Results: Ten clinical trials were included in our meta-analysis. Eradication odds ratio (OR) was available for 1469 patients (708 in the probiotics supplementation group and 761 in the control group). The pooled OR by intention-to-treat analysis and by per-protocol analysis in the probiotics supplementation versus without probiotics was 2.066 [95% confidence interval (CI), 1.398-3.055] and 2.321 (95% CI, 1.715-3.142), respectively. The pooled OR of incidence of total side effects was significantly decreased in the probiotics supplementation group (OR=0.305; 95% CI, 0.117-0.793) by the random model without significant publication bias.Conclusions: Lactobacillus-containing and Bifidobacterium-containing probiotic compound preparation during initial H. pylori eradication therapy in the adult may have beneficial effects on eradication rate and incidence of total side effects.